fospropofol (Discontinued)

Brand and Other Names:Lusedra
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Dosing & Uses

AdultPediatric

This drug has been discontinued in the United States

N/A

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Interactions

Interaction Checker

and fospropofol

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    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Paresthesia

            Pruritus

            Hypoxemia

            1-10%

            Headache

            Hypotension

            Nausea/vomiting

            Unresponsiveness to tactile or nociceptive stimuli

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            Warnings

            Contraindications

            Hypersensitivity

            Situations where general anesthesia is contraindicated

            Cautions

            May cause loss of spontaneous respiration, hypoxemia, hypotension

            Not recommended for labor & delivery

            Caution in respiratory disease

            Patient may become unresponsive or minimally responsive to painful stimuli

            Caution in hepatic or renal impairment

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            Pregnancy & Lactation

            Pregnancy Category: B

            Lactation: enters breast milk; not recommended

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Sedative-hypnotic, prodrug of propofol; interacts with GABA A receptor

            Pharmacokinetics

            Peak Plasma Time: 2-4 min to propofol; 8-12 min of propofol from fospropofol:

            Protein Bound: 98%

            Onset: ~8 min

            Half-life: 0.8-0.96 hr

            Duration: ~5 min (time to fully alert)

            Vd: 0.26-0.4 L/kg

            Metabolism: by alk phos to propofol, formaldehyde & phosphate

            Excretion: Urine

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            Administration

            IV Incompatibilities: midazolam; meperidine

            IV Administration

            Ready-to-use formulation

            Administer through a secure, freely flowing, peripheral line

            Flush infusion line with NS before & after administration

            Compatible common fluids: D5W, D5/0.2%NaCl, D5/0.5NS, D5/LR, LR, NS, 0.5NS

            Do not coadminister other drugs

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