Close
New

Medscape is available in 5 Language Editions – Choose your Edition here.

 

gonadorelin (Rx)Brand and Other Names:Lutrepulse

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

lyophilized powder for injection

  • 0.8mg/vial
more...

No Longer Available in the United States

5 mcg q90min SC/IV

Other Indications & Uses

Induction of ovulation in women with primary hypothalamic amenorrhea

Not applicable

Next

Adverse Effects

Frequency Not Defined

Inj site reaction

Ovarian hyperstimulation

Thrombophlebitis

Previous
Next

Warnings

Contraindications

Hypersensitivity to gonadorelin

Ovarian cysts

Hormonally-dependent tumors

Any condition potentially exacerbated by pregnancy

Cautions

Monitor ovarian function

Possibility of multiple gestation

Should be administered only by physician familiar with reproductive medicine & pulsatile LHRH/GnRH delivery

Previous
Next

Pregnancy & Lactation

Pregnancy Category: X

Lactation: not recommended

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

more...
Previous
Next

Pharmacology

Vd: 9-15 L

Half-Life, Initial: 2-10 min

Half-Life, Terminal: 10-40 min

Metabolism: to small peptides

Excretion: urine

Mechanism of Action

Recombinant human LHRH (GnRH)

Previous
Next

Administration

IV/SC Preparation

Reconstitute aseptically with 8 mL of diluent provided (NS) immediately prior to use

Shake for a few seconds

IV/SC Administration

Administer using a pulsatile pump

Set to deliver 25 or 50 mcL based upon dose selected, over a pulse period of 1 min & a pulse frequency of 90 min

Previous
Next

Images

Previous
Next

Formulary

FormularyPatient Discounts

To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

Adding plans allows you to:

  • View the formulary and any restrictions for each plan.
  • Manage and view all your plans together – even plans in different states.
  • Compare formulary status to other drugs in the same class.
  • Access your plan list on any device – mobile or desktop.

The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
Add or Remove Plans
Plans for
Select State:
Non-Medicare PlansMedicare Plans

Select a box to add or remove a plan.

Select a class to view formulary status for similar drugs

Additional Offers
Email to Patient

From:

To:

The recipient will receive more details and instructions to access this offer.

By clicking send, you acknowledge that you have permission to email the recipient with this information.

Email Forms to Patient

From:

To:

The recipient will receive more details and instructions to access this offer.

By clicking send, you acknowledge that you have permission to email the recipient with this information.

Previous
 
 
 
All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.