Dosing & Uses
Dosage Forms & Strengths
Tinea Corporis & Tinea Cruris
Indicated for the treatment of tinea corporis nad corporis caused by the organisms Trichophyton rubrum and Epidermophyton floccosum
Apply cream to affected area and ~1-inch surrounding area(s) qDay for 1 week
Indicated for the treatment of interdigital tinea pedis caused by the organisms Trichophyton rubrum and Epidermophyton floccosum
Apply cream to affected area and ~1-inch surrounding area(s) qDay for 2 weeks
<18 years: Safety and efficacy not established
Application site reactions
For topical use only; not for ophthalmic or intravaginal administration
May inhibit CYP2C19 and CYP3A4 isoenzymes; particularly when treating large surface areas (ie, moderate-to-severe tinea cruris) that result in increased luliconazole systemic exposure
Pregnancy & Lactation
Pregnancy Category: C
Lactation: Unknown if distributed in human breast milk
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Imidazole antifungal that alters the fungal cell membrane; interacts with 14-alpha demethylase (an enzyme necessary for conversion of lanosterol to ergosterol), inhibiting the synthesis of ergosterol which is an essential component of the membrane; increases cell permeability causing leakage of cellular contents
- Peak plasma concentration: 0.4 ng/mL (first dose); 0.93 ng/mL (final dose)
- Peak plasma time: 16.9 hr (first dose); 5.8 hr (final dose)
- AUC: 6.88 ng•hr/mL (first dose); 18.74 ng•hr/mL (final dose)
- Peak plasma time: 21 hr (first dose); 6.5 hr (final dose)
- Peak plasma concentration: 4.91 ng/mL (first dose); 7.36 ng/mL (final dose)
- AUC: 85.1 ng•hr/mL (first dose); 121.74 ng•hr/mL (final dose)
Protein bound: >99%
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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.
|1||This drug is available at the lowest co-pay. Most commonly, these are generic drugs.|
|2||This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.|
|3||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.|
|NC||NOT COVERED – Drugs that are not covered by the plan.|
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.