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magnesium oxide (OTC)Brand and Other Names:Mag-Ox 400, Uro-Mag, more...Mag-Caps

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

capsule

  • 140mg (equivalent to 84.5mg [6.93mEq] elemental magnesium)

tablet

  • 400mg (equivalent to 240mg [20mEq] elemental magnesium)
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Recommended Daily Intake (Elemental Mg)

Females

  • 19-30 yr: 310 mg/day PO
  • 19-30 yr (pregnant): 350 mg/day PO
  • >31 yr: 320 mg/day PO
  • >31 yr (pregnant): 360 mg/day PO

Males

  • 19-30 yr: 400 mg/day PO
  • >31 yr: 420 mg/day PO

Magnesium Supplementation

Tablet (Mag-Ox): 1-2 tablets PO qDay

Capsule (Uro-Mag): 1-5 capsules PO qDay

Antacid

Tablet (Mag-Ox): 1 tablet PO qDay or q12hr; not to exceed 2 tablets/day

Renal Impairment

CrCl <30 mL/min: Caution; monitor for hypermagnesemia

Administration

Take with food

Dosage Forms & Strengths

capsule

  • 140mg (equivalent to 84.5mg [6.93mEq] elemental magnesium)

tablet

  • 400mg (equivalent to 240mg [20mEq] elemental magnesium)
more...

Recommended Daily Intake (Elemental Mg)

1-3 years: 80 mg/day PO

4-8 years: 130 mg/day PO

9-13 years: 240 mg/day PO

14-18 years

  • Females: 360 mg/day PO
  • Pregnant females: 400 mg/day PO
  • Males: 410 mg/day PO

Renal Impairment

CrCl <30 mL/min: Caution; monitor for hypermagnesemia

Administration

Take with food

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Interactions

Interaction Checker

magnesium oxide and

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    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Diarrhea with excessive dose

            Gastrointestinal irritation

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            Warnings

            Contraindications

            Hypersensitivity

            Cautions

            Normal serum magnesium ~1.5-2.5 mg/dL

            Laxative effect

            Magnesium supplementation may exacerbate

            Caution with renal impairment

            Caution with myasthenia gravis or other neuromuscular diseases

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            Pregnancy & Lactation

            Pregnancy Category: A; 350-400 mg/day elemental Mg recommended during pregnancy

            Lactation: Distributed in breast milk; 310-360 mg/day elemental Mg recommended during lactation

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Mineral; cofactor in many enzymatic reactions and essential for various metabolic functions (eg, phosphate transfer, muscle contraction, nerve conduction)

            Pharmacokinetics

            Absorption: Inversely proportional to dose; ~50% with controlled dietary intake, compared with 15-30% with high dose

            Distribution sites: 50-60% (bone); 1-2% (extracellular fluid)

            Protein Bound: 30% (albumin)

            Excretion: Urine

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