magaldrate (Discontinued)Brand and Other Names:Riopan

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

oral suspension

  • 540mg/5mL

oral suspension: magaldrate-simethicone

  • 540mg - 40mg/5mL
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Heartburn, Sour Stomach, & Acid Indigestion

5-10 mL (1-2 teaspoonfuls; 540-1080 mg) between meals and HS; not to exceed 80 mL (16 teaspoonfuls) in 24-hour period

Other Indications & Uses

Hyperphosphatemia, Mg deficiency

Off-label: Gastric & duodenal ulcer, GERD

Neutralizes gastric acid, increases gastric pH

Heartburn, Sour Stomach, & Acid Indigestion

Safety & efficacy not established

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Adverse Effects

>10%

Aluminum oxide

  • Chalky taste
  • Constipation
  • Fecal impaction
  • Stomach cramps

Frequency Not Defined

Aluminum oxide

  • Nausea
  • Vomiting
  • Aluminum intoxication
  • Hypophosphatemia
  • Osteomalacia

Magnesium oxide

  • Diarrhea
  • Hypermagnesemia
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Warnings

Contraindications

Hypersensitivity to any component

Cautions

Renal failure, Mg-restricted diet

May increase or decrease rate &/or degree of absorption of concomitantly administered oral drugs by changing GI transit time or by binding the drug

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Pregnancy & Lactation

Pregnancy Category: Magaldrate: ?; simethicone: C

Lactation: not known whether aluminum oxide or magnesium oxide is excreted in breast milk, use caution

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Duration:

For antacid action, dependent on gastric emptying time:

  • Fasting state: 20-60 min
  • 1hr after meals: up to 3 hr on the fasting

Excretion:

Aluminium oxide: absorbed Al ions are eliminated in the urine (0.1-0.5 mg of Al in aluminium-containing antacid is absorbed from standard daily doses of antacid), insoluble or poorly absorbed Al salts in the intestines are excreted in the feces

Magnesium oxide: absorbed Mg ions (up to 30%) are eliminated in urine, unabsorbed drug is excreted in feces

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