magnesium hydroxide/mineral oil (OTC)Brand and Other Names:Phillips' M-O

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

magnesium hydroxide/mineral oil

oral solution

  • 1.25mL/5mL
  • 300mg/5mL
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Laxative

30-60 mL/day (400 mg/5 mL) PO qD HS or divided doses

15-30 mL/day (800 mg/5mL) PO qDHS or divided doses

Antacid

Liquid: 5-15 mL (400 mg/5 mL) PO PRN up to QID

Tablet: (311 mg): 2-4 tablets q4hr PRN up to QID

Other Indications & Uses

Constipation

Dosage Forms & Strengths

magnesium hydroxide/mineral oil

oral solution

  • 1.25mL/5mL
  • 300mg/5mL
more...

Laxative

<6 years old: Not recommended

6-11 years old

  • 15-30 mL/day PO qHS or divided doses
  • 7.5-15 mL/day qHS or divided doses

≥12 years old

  • 30-60 mL/day (400 mg/5 mL) PO qD HS or divided doses
  • 15-30 mL/day (800 mg/5mL) PO qDHS or divided doses

Antacid

Liquid

  • <12 years old: Not recommended
  • ≥12 years old: 5-15 mL (400 mg/5 mL) PO PRN up to QID

Tablet (311 mg)

  • <12 years old: Not recommended
  • ≥12 years old: 2-4 tablets q4hr PRN up to QID
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Interactions

Interaction Checker

magnesium hydroxide/mineral oil and

No Results

     
     activity indicator 
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    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Hypotension

            Respiratory depression

            Lipid pneumonia if taken when reclined

            Excessive bowel activity

            Abdominal cramping

            Electrolyte imbalance

            Muscle weakness

            Anal pruritus and irritation

            Laxative dependence (Avoid chronic use)

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            Warnings

            Contraindications

            Renal failure, existing electrolyte imbalance, appendicitis symptoms, acute surgical abdomen, myocardial damage, heart block, fecal impaction, rectal fissures, intestinal obstruction or perforation, pregnant, bedridden, dysphagia

            If currently taking stool softener

            Cautions

            Renal insufficiency, Mg-restricted diet

            If taken at bedtime, pt should not be reclining to avoid aspiration of oil droplets

            Do not take within 2 hr of meals; may interfere with food nutrients & vitamins absorption

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            Pregnancy & Lactation

            Pregnancy Category: C for mineral oil, B for magnesium hydroxide

            Lactation: use cautiously in breast feeding as it is unknown whether mineral oil is excreted into breast milk

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Onset: 30 min-6 hr

            Bioavailabilty: 15-30% of magnesium hydroxide, 30-60% for emulsified mineral oil

            Excretion: Mg is mainly excreted by kidney

            Mechanism of Action

            Saline cathartic effect from magnesium hydroxide & emollient laxative effect from mineral oil

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