magnesium hydroxide/mineral oil (OTC)

Brand and Other Names:Phillips' M-O
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

magnesium hydroxide/mineral oil

oral solution

  • (300 mg/1.25mL)/5mL
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Laxative

45-60 mL/day PO qDay HS or divided doses

Antacid

Liquid: 5-15 mL PO PRN up to q6hr

Dosage Forms & Strengths

magnesium hydroxide/mineral oil

oral solution

  • (300 mg/1.25mL)/5mL
more...

Laxative

<6 years

  • Not recommended

6-12 years

  • 20-30 mL/day PO qHS or divided doses

>12 years

  • 45-60 mL/day PO qDay HS or divided doses

Antacid

Liquid

  • <12 years old: Not recommended
  • ≥12 years old: 5-15 mL PO PRN up to q6hr
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Interactions

Interaction Checker

and magnesium hydroxide/mineral oil

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Hypotension

            Respiratory depression

            Lipid pneumonia if taken when reclined

            Excessive bowel activity

            Abdominal cramping

            Electrolyte imbalance

            Muscle weakness

            Anal pruritus and irritation

            Laxative dependence (Avoid chronic use)

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            Warnings

            Contraindications

            Existing electrolyte imbalance, appendicitis symptoms, acute surgical abdomen, fecal impaction, intestinal obstruction or perforation, dysphagia, bedridden patients

            Co-administration with stool softener

            < 6 years

            Hypersensitivity to drug or formulation components

            Cautions

            Renal insufficiency, Mg-restricted diet

            If taken at bedtime, patient should not be reclining to avoid aspiration of oil droplets

            Do not take within 2 hr of meals; may interfere with food nutrients & vitamins absorption

            Use caution in patients with severe renal impairment

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            Pregnancy & Lactation

            Pregnancy Category: C for mineral oil, B for magnesium hydroxide

            Lactation: Use cautiously in breast feeding as it is unknown whether mineral oil is excreted into breast milk

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Saline cathartic effect from magnesium hydroxide & emollient laxative effect from mineral oil

            Pharmacokinetics

            Onset: 30 min-6 hr

            Bioavailabilty: 15-30% of magnesium hydroxide, 30-60% for emulsified mineral oil

            Excretion: Mg is mainly excreted by kidney

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