Dosing & Uses
Dosage Forms & Strengths
- 1504mg/powder sachet (elemental magnesium/sachet: 243mg [20mEq])
Dietary supplement to treat or reduce the risk of magnesium deficiency
Dose based on elemental magnesium (Mg) 243-486 mg PO daily
If 486 mg/day administered, give as 2 doses 4-8 hr apart
Indication: Recommended to treat or reduce the risk of hypomagnesemia in individuals diagnosed with a cardiovascular condition (eg, congestive heart failure, hypertension, tachyarrhythmia, atherosclerosis); gastrointestinal condition (eg, Crohn’s disease, ulcerative colitis, celiac disease); electrolyte abnormality (eg, hyponatremia, hypokalemia, hypocalcemia, hypophosphatemia, refractory potassium depletion); diabetes mellitus; nephrolithiasis; or osteoporosis
243 mg elemental Mg provides ~60% of recommended daily intake (RDI)
RDI for adults is 400 mg/day
Other ingredients: Xylitol, citric acid, natural and artificial orange flavor, dextrin, sucralose
Mix with 4-8 oz of water, stir well and drink
May take with or without food
Store in a dry location at 59-86°F (15-30°C)
Safety and efficacy not established
Serious - Use Alternative
Significant - Monitor Closely
Frequency Not Defined
Known hypersensitivity to proton pump inhibitors
Patients who experience a sudden change in bowel habits
Coadministration with calcium channel blockers; magnesium may enhance the hypotensive effect of the calcium channel blockers
May enhance neuromuscular-blocking effect of neuromuscular-blocking agents
Avoid concomitant use of calcium polystyrene sulfonate
High fat content of food decreases magnesium absorption
Pregnancy & Lactation
Pregnancy Category: B; crosses placenta, physician should guide dosage for pregnant women
Lactation: Excreted in human breast milk; concentrations remain constant during the first year of lactation; effects of prolonged increments in magnesium are not known
Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Plays an important role in more than 300 biochemical reactions in the body, participating in neuromuscular activity, excitation-contraction coupling, temperature regulation, detoxification reactions, synthetic processes (including DNA and RNA synthesis), and energy production through carbohydrate metabolism
At normal intake levels, ionic fractional absorption is 25-50%
~50% stored in bone; remaining 50% intracellular
~1% of total body magnesium is in plasma (55-70% ionized, 20-30% protein bound, 5-15% complexed with anions)
Excretion: Principally in urine