trimagnesium citrate anhydrous (OTC)

Brand and Other Names:Magnitria
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

oral powder

  • 1504mg/powder sachet (elemental magnesium/sachet: 243mg [20mEq])
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Magnesium Supplementation

Dietary supplement to treat or reduce the risk of magnesium deficiency

Dose based on elemental magnesium (Mg) 243-486 mg PO daily

If 486 mg/day administered, give as 2 doses 4-8 hr apart

Dosing Considerations

Indication: Recommended to treat or reduce the risk of hypomagnesemia in individuals diagnosed with a cardiovascular condition (eg, congestive heart failure, hypertension, tachyarrhythmia, atherosclerosis); gastrointestinal condition (eg, Crohn’s disease, ulcerative colitis, celiac disease); electrolyte abnormality (eg, hyponatremia, hypokalemia, hypocalcemia, hypophosphatemia, refractory potassium depletion); diabetes mellitus; nephrolithiasis; or osteoporosis

243 mg elemental Mg provides ~60% of recommended daily intake (RDI)

RDI for adults is 400 mg/day

Other ingredients: Xylitol, citric acid, natural and artificial orange flavor, dextrin, sucralose

Administration

Mix with 4-8 oz of water, stir well and drink

May take with or without food

Store in a dry location at 59-86°F (15-30°C)

Safety and efficacy not established

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Interactions

Interaction Checker

and trimagnesium citrate anhydrous

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            Adverse Effects

            Frequency Not Defined

            Asthenia

            Dizziness

            Hypotension

            Respiratory depression

            Diarrhea

            Abdominal cramping

            Electrolyte imbalance

            Hypermagnesemia

            Muscle weakness

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            Warnings

            Contraindications

            Known hypersensitivity to proton pump inhibitors

            GI obstructions

            Hypermagnesemia

            Cautions

            Kidney dysfunction

            Patients who experience a sudden change in bowel habits

            Coadministration with calcium channel blockers; magnesium may enhance the hypotensive effect of the calcium channel blockers

            May enhance neuromuscular-blocking effect of neuromuscular-blocking agents

            Avoid concomitant use of calcium polystyrene sulfonate

            High fat content of food decreases magnesium absorption

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            Pregnancy & Lactation

            Pregnancy Category: B; crosses placenta, physician should guide dosage for pregnant women

            Lactation: Excreted in human breast milk; concentrations remain constant during the first year of lactation; effects of prolonged increments in magnesium are not known

            Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Plays an important role in more than 300 biochemical reactions in the body, participating in neuromuscular activity, excitation-contraction coupling, temperature regulation, detoxification reactions, synthetic processes (including DNA and RNA synthesis), and energy production through carbohydrate metabolism

            Absorption

            At normal intake levels, ionic fractional absorption is 25-50%

            Distribution

            ~50% stored in bone; remaining 50% intracellular

            ~1% of total body magnesium is in plasma (55-70% ionized, 20-30% protein bound, 5-15% complexed with anions)

            Elimination

            Excretion: Principally in urine

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