Brand and Other Names:Maxidex
- Classes: Corticosteroids, Ophthalmic
Dosing & Uses
Dosage Forms & Strengths
Inflammatory Ocular Conditions
1-2 gtt q1hr during day and q2hr at night, THEN
Decrease to 1 gtt q4hr, THEN
Decrease to 1 gtt TID-QID
See Also Combo
With tobramycin (TobraDex)
Other Indications & Uses
Potent corticosteroid indicated for many ocular conditions: Iritis, uveitis, keratitis, etc; it is essential for proper monitoring of patients while on steroid eye drops
Safety and efficacy not established
Raised intraocular pressure (25% )
Cataract (4% )
Open-angle glaucoma, optic nerve damage, and defects in visual acuity and field of vision (after prolonged use)
Transient ocular stinging, burning, local irritation, ocular discharge, ocular discomfort or pain, foreign body sensation, hyperemia, abnormal vision/blurring, pruritus, lid margin crusting, sticky sensation, increased fibrin, dry eye, conjunctival edema, corneal staining, keratitis, tearing, edema, irritation, corneal ulcer, browache, eyelid erythema, corneal edema, infiltrate, corneal erosion, mydriasis, ptosis, epithelial punctate keratitis, and possible corneal or scleral malacia, [posterior subcapsular cataracts] (prolonged use)
Glaucoma, epithelial defect, epithelial herpes simplex keratitis, acute infectious stages of vaccinia, varicella, and other diseases of cornea & conjunctiva
Mycobacterial infection of eye, fungal diseases
Short term treatment is best, if possible, because of the ocular side effects of glaucoma, secondary infection (herpes simplex), cataract formations, etc
Reduce to lowest dose, use suspension last, wait 5min between gtts if using multiple drugs
Pregnancy & Lactation
Pregnancy Category: C
Lactation: excretion in milk unknown/not recommended
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Absorbed: into the aqueous humor and systemic
Mechanism of Action
Inhibits the inflammatory response to mechanical, chemical, or immunologic agents
Corticosteroids inhibit edema, fibrin deposition, capillary dilatation, and migration of leukocytes and phagocytes in the acute inflammatory response
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