mephobarbital (Discontinued)Brand and Other Names:Mebaral

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 32mg
  • 50mg
  • 100mg
more...

Sedation

32-100 mg PO TID/QID; optimum dose is 50 mg PO TID/QID

Epilepsy

400-600 mg PO qDay; start with small dose and gradually increase over 4-5 days until optimum dosage determined

Other Indications & Uses

Anxiety; grand mal, petit mal seizures

Dosage Forms & Strengths

tablet

  • 32mg
  • 50mg
  • 100mg
more...

Sedation

16-32 mg PO TID/QID

Epilepsy

< 5 years old: 16-32 mg PO TID/QID

> 5 years old: 32-64 mg PO TID/QID

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Interactions

Interaction Checker

mephobarbital and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Common

            • Somnolence

            Less Common

            • Bradycardia, hypotension, hypoventilation
            • Agitation, confusion, hyperkinesia, ataxia, CNS depression, nightmares, nervousness
            • Constipation, nausea, vomiting

            Rare

            • Fever
            • Headache
            • Rash
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            Warnings

            Contraindications

            Barbiturate sensitivity, porphyria, liver disease, severe respiratory disease

            Cautions

            Reduce dose in hepatic/renal impairment

            Excreted in breast milk

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            Pregnancy & Lactation

            Pregnancy Category: D

            Lactation: excreted in breast milk; use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Half-Life: >30 hr

            Onset: 30-60 min

            Duration: 10-16 hr

            Bioavailability: 50%

            Metabolism: N-demethylation, then glucuronate or sulfate conjugation

            Metabolites: phenobarbital

            Excretion: urine

            Enzymes induced: CYP1A2, CYP2C9/10, CYP3A4

            Mechanism of Action

            Depress cortical & cerebellar function

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