mecamylamine (Rx)

Brand and Other Names:
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 2.5mg
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Hypertension

Indicated for moderately severe-to-severe essential hypertension and uncomplicated malignant hypertension

2.5 mg PO BID intially; may increase by 2.5 mg increments at interval not less than 2 days

Average total daily dose is 25 mg (in 3 divided doses); however, as little as 2.5 mg/day may be sufficient

Administration

Take after meals; may cause more gradual absorption and smoother control of excessively high blood pressure

Safety and efficacy not established

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Interactions

Interaction Checker

and mecamylamine

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Common

            • Orthostatic hypotension
            • Dizziness, lightheadedness
            • Fatigue
            • Sedation
            • Constipation
            • Dry mouth
            • Nausea/Vomiting
            • Xerostomia

            Serious

            • Syncope
            • Seizure
            • Tremor
            • Paralytic ileus
            • Chorea
            • Dysuria
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            Warnings

            Contraindications

            Hypersensitivity to mecamylamine

            Coronary insufficiency, glaucoma, recent MI, pyloric stenosis, renal insufficiency, uremia

            Do not use w/antibiotics, sulfonamides

            Cautions

            Arteriosclerosis, bladder neck obstruction, urethral stricture, cerebral insufficiency, gastrointestinal obstruction, prostatic hypertrophy

            Potentiation of hypotensive effects due to excessive heat, fever, infection, hemorrhage, pregnancy, anesthesia, alcohol consumption, salt depletion, or diarrhea

            Avoid abrupt withdrawal

            Rarely used

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: may cross into the breast milk, use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Ganglionic blocker, inhibits acetylcholine at autonomic ganglia resulting in decreased blood pressure

            Pharmacokinetics

            Half-Life: 24 hr

            Onset: 0.5-2 hr

            Duration: 6-12 hr

            Excretion: urine 100%

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            • View the formulary and any restrictions for each plan.
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            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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