Congestive Heart Failure
2-6 g/day PO div BID-TID
4 g PO TID x 6 weeks
Treatment of Steatorrhea in Children with Cystic Fibrosis
30 mg/kg day x 4 months in addition to pancreatic enzyme supplementation
Cystathionine Beta-Synthase Deficient Homocystinuria (Orphan)
Indicated for treatment of cystathionine beta-synthase deficient homocystinuria
Orphan indication sponsor
- Johan L. Van Hove, MD, PhD; Department of Pediatrics/University of Colorado DE; 13121 E. 17th Ave; PO Box 6508; Aurora, CO 80045
CHF, hypertension, hypercholesterolemia, cystic fibrosis, antiatherogenic effects
Other uses include seizure disorders (epilepsy), autism, ADHD, retinal degeneration, diabetes, alcoholism, improve mental performance & antioxidant.
In human clinical studies taurine lowered blood pressure
CHF: Seems to improve left ventricular function in patients with New York Heart Association functional class II to IV
Acute Hepatitis: Might improve liver function
In animal studies taurine lowered lipid levels, but human studies are contradictory
Serious - Use Alternative
Significant - Monitor Closely
Monitor pts with CHF
Pregnancy & Lactation
Pregnancy Category: avoid use
Lactation: avoid use
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Excretion: feces & urine
Mechanism of Action
Antioxidant, putative hypocholesterolemic, hypotensive, antiatherogenic & detoxifying activities
May also have steatorrhea-reducing activity in pts with cystic fibrosis & putative antidiabetic, inotropic & antiseizure activities