meprobamate (Rx)

Brand and Other Names:
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Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

tablet: Schedule IV

  • 200mg
  • 400mg
more...

Anxiety

1200-1600 mg/day PO divided q6-8hr; not to exceed 2.4 g/day

Preoperative Sedation

400 mg PO before the procedure

Renal Impairment

CrCl 10-50 mL/min: Change frequency of administration to every 9-12hr

CrCl <10 mL/min: Change frequency of administration to 12-18hr

Hepatic Impairment

Use caution

Dosage Forms & Strengths

tablet: Schedule IV

  • 200mg
  • 400mg
more...

Anxiety

<6 years old: Not recommended

6-12 years old: 100-200 mg PO q8-12hr

>12 years old: 1200-1600 mg/day PO divided q8-12hr; not to exceed 2.4 g/day

Preoperative Sedation

200 mg PO prior to procedure

Not drug of choice in elderly because of potential physical and psychological dependence

Use lowest effective dose to avoid oversedation

Anxiety

Lower initial dose; adjust more gradually; 200 mg PO q8-12hr

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Interactions

Interaction Checker

and meprobamate

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Common

            • Abnormal ECG, palpitations, tachyarrhythmia
            • Asthenia, ataxia, dizziness, EEG abnormality, euphoria, fast, excitement, paradoxical, headache, paresthesia, slurred speech, somnolence, vertigo
            • Hives, maculopapular eruption, erythematous
            • Diarrhea, nausea, vomiting
            • Disorder of accommodation (ocular)

            Serious

            • Cardiac dysrhythmia, hypotension crisis, syncope
            • Bullous dermatosis (rare), Stevens-Johnson syndrome (rare)
            • Agranulocytosis, aplastic anemia, leukopenia
            • Anaphylaxis (rare)
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            Warnings

            Contraindications

            Hypersensitivity, allergy to related drugs (eg, carisoprodol)

            History of porphyria

            Cautions

            Hypersensitivity may occur

            May impair physical or mental abilities due to CNS depression

            Secreted into breast milk; avoid during breastfeeding

            Caution in patientw with depression or suicidal tendencies

            Caution in hepatic/renal impairment or seizure disorder

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            Pregnancy & Lactation

            Pregnancy Category: D

            Lactation: secreted into breast milk at 2-4x plasma concentration; avoid

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Carbamate derivative; inhibitory effects in thalamus, limbic system; may inhibit multineural spinal reflexes

            Mild sedative, anticonvulsant, muscular relaxant effects

            Pharmacokinetics

            Absorption: well-absorbed from GI tract

            Half-Life: 6-16 hr

            Onset: <1 hr

            Peak plasma time: 1-3hr

            Peak plasma concentration: 5-30 mcg/mL (400 mg dose)

            Protein Bound: 20%

            Metabolism: Liver

            Metabolites: Inactive

            Excretion: Urine (8-20%); feces (10%)

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            Images

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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