Brand and Other Names:Mepron
- Classes: Antimalarials
Dosing & Uses
Dosage Forms & Strengths
Malaria (P. falciparum)
1000 mg (with proguanil 400 mg) PO qDay x3 days
Pneumocystis Carinii Pneumonia
Treatment: 750 mg PO BID x21 days
Prophylaxis: 1500 mg/day PO, qDay or divided BID, with food
See also combo with proguanil
Dosage Forms & Strengths
Malaria (P. Falciparum)
11-20 kg: 250 mg (with proguanil 100 mg)
21-30 kg: 500 mg (with proguanil 200 mg)
31-40 kg: 750 mg (with proguanil 300 mg)
All PO qDay x3 days
Serious - Use Alternative
Significant - Monitor Closely
Abdominal pain (4-21%)
Amylase increased (7-8%)
BUN/creatinine increased (<1%)
Liver enzymes elevated (4-8%)
Oral moniliasis (5-10%)
Taste perversion (<3%)
Monotherapy for malaria
Admin proguanil concomitantly for malaria
Admin w/ food
Pregnancy & Lactation
Pregnancy Category: C
Lactation: excretion in milk unknown; use with caution
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Absorption: significantly increased with a high-fat meal
Distribution: 3.5 L/kg
Protein Bound: >99%
Metabolism: undergoes enterohepatic recirculation
Bioavailability: tablet: 23%; suspension: 47%
Half-life, elimination: 2-3 d
Excretion: feces (94% as unchanged drug)
Mechanism of Action
Inhibits electron transport chain in Plasmodium
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