Close
New

Medscape is available in 5 Language Editions – Choose your Edition here.

 

metyrapone (Rx)Brand and Other Names:Metopirone

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

capsule

  • 250mg
more...

ACTH Diagnostic Test

Single dose test

  • 30 mg/kg PO at midnight; not to exceed 3 g/dose

Multiple dose test

  • 750 mg PO q4hr x6 doses

Administration

4 days prior to administration, collect and test a control 24-hour urine specimen for 17-hydroxycorticosteroids (17-OHCS) or 17-Ketogenic steroids (17-KGS) (alternatively, urinary tetrahydrodeoxycortisol, THS)

On the following day, perform corticotropin test to rule out adrenocortical insufficiency

May take with milk or food to reduce GI irritation

Cushing's Syndrome Treatment (Off-label)

250 mg PO q4hr; not to exceed 6 g/day

Dosage Forms & Strengths

capsule

  • 250mg
more...

ACTH Diagnostic Test

15 mg/kg or 300 mg/m² PO q4hr x6 doses; manufacturer recommends minimum single dose of 250 mg 

Administration

4 days prior to administration, collect and test a control 24-hour urine specimen for 17-hydroxycorticosteroids (17-OHCS) or 17-Ketogenic steroids (17-KGS) (alternatively, urinary tetrahydrodeoxycortisol, THS)

On the following day, perform corticotropin test to rule out adrenocortical insufficiency

May take with milk or food to reduce GI irritation

Next

Interactions

Interaction Checker

metyrapone and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            Sort by :  
             activity indicator 
            Previous
            Next

            Adverse Effects

            Frequency Not Defined

            Abdominal discomfort

            Bone marrow depression (rare)

            Decr leukocyte count (rare)

            Dizziness

            Fall in arterial blood pressure

            Headache

            Nausea

            Pulse rate incr

            Sedation

            Vertigo

            Previous
            Next

            Warnings

            Contraindications

            Adrenocortical insufficiency

            Hypersensitivity

            Cautions

            May cause CNS depression, which may impair physical or mental abilities

            Discontinue all corticosteroid therapy prior to, and during metyrapone test

            Discontinue phenytoin at least 2 wk before metyrapone test

            Pregnancy/lactation

            Previous
            Next

            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: unknown, use with caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
            Previous
            Next

            Pharmacology

            Mechanism of Action

            Inhibits formation of cortisol, corticosterone, and aldosterone

            Pharmacokinetics

            Half-life elimination: 1.9 hr (metyrapone)

            Onset: Within 24 hr of administration (peak steroid excretion)

            Peak Plasma: 1.2 mcg/mL

            Metabolism: Liver and kidney; metabolized to an active reduced metabolite

            Enzyme Inhibited: 11-beta-hydroxylase

            Excretion: ~40% in urine (37% as glucuronide conjugates, 3% as the reduced metabolite and 0.5% unchanged)

            Previous
            Next

            Images

            Previous
            Next

            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
            Add or Remove Plans
            Plans for
            Select State:
            Non-Medicare PlansMedicare Plans

            Select a box to add or remove a plan.

            Select a class to view formulary status for similar drugs

            Additional Offers
            Email to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Email Forms to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Previous
             
             
             
            All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.