Brand and Other Names:MetroCream, MetroGel, more...MetroLotion, Noritate
- Classes: Antibacterials, Topical
Dosing & Uses
Dosage Forms & Strengths
- 1% (MetroGel)
- 0.75% (MetroCream)
- 1% (Noritate)
- 0.75% (MetroLotion)
Indicated for the topical treatment of inflammatory lesions of rosacea
1%: Apply topically qDay to affected area(s)
0.75%: Apply topically BID to affected area(s)
Cleanse treated areas prior to application
Apply thin film and rub into skin
Cosmetics may be applied ≥5 minutes after application
Safety and efficacy not established
Serious - Use Alternative
Significant - Monitor Closely
Skin dryness (25.4%)
Skin scaling (24.6%)
Cutaneous stinging/burning (10.3%)
Frequency Not Defined
Application site reaction
Tearing of eyes
Skin and eye irritation
For external use only
Avoid contact with eyes; tearing may occur
Nitroimidazole; use caution with evidence or history of blood dyscrasia
Discontinue use if dermatitis occurs
Administer with caution in patients with CNS diseases due to risk of numbess or paresthesia of an extremity
Pregnancy & Lactation
Pregnancy Category: B
Lactation: Unknown if excreted in human milk; caution advised
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Mechanism by which metronidazole acts in the treatment of rosacea is unknown, but appears to include an anti-inflammatory effect
Inhibits nucleic acid synthesis by disrupting DNA
Peak Plasma Time: 6-10 hr
Peak Plasma Concentration: 32 ng/mL (<1% of PO dose)
AUC: 595 ng•hr/mL (<1% of single PO dose)
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|1||This drug is available at the lowest co-pay. Most commonly, these are generic drugs.|
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