Brand and Other Names:Miochol E
- Classes: Miotics, Direct-Acting
Dosing & Uses
Dosage Forms & Strengths
powder for injection
Miosis During Ocular Surgery
0.5-2 mL of 1% solution intraocular instillation during surgery
Miosis occurs promptly and persists for approximately 10 minutes
Reconstitute vial with 2 mL supplied diluent to obtain 1% solution; use immediately
Instill gently into anterior chamber of eye with suitable atraumatic cannula
May use 2% pilocarpine or 0.25% physostigmine topically immediately after surgery before application of dressing to maintain miosis
For cataract surgery, instill only after delivery of lens
Safety & efficacy not established
Frequency Not Defined
- Corneal edema
- Corneal clouding
- Corneal decompensation
- Breathing difficulty
Use reconstituted solution immediately; aqueous solution unstable
Instill gently; forceful jet may rupture the hyaloid, cause vitreous loss, or traumatize/perforate iris
Systemic effects (rare) can cause problems for patients with asthma, acute heart failure, GI spasm, peptic ulcer disease, urinary tract obstruction, acute heart failure, and hyperthyroidism
Pregnancy & Lactation
Pregnancy Category: C
Lactation: Excretion in milk unknown; use with caution
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Direct-acting parasympathomimetic neurotransmitter; causes contraction of sphincter muscles of the iris, which results in miosis and contraction of ciliary muscle and leads to accomodation spasm
Onset of action: Rapid
Duration: 6 hr
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