measles mumps and rubella vaccine, live (Rx) - M-M-R-II

 
 
 

Adult Dosing & Uses

Immunization Against Measles, Mumps & Rubella

19-49 years old: 0.5 mL SC; second dose may be adminsitered 28 days apart

>50 years old: 0.5 mL SC; administer 1 dose only

Other Information

Mainly administered to children

Up-to-date vaccination schedules available at www.cdc.gov/nip/publications

Other Indications & Uses

2nd dose recommended for: Student in postsecondary eduction; recent exposure; occupational risk; previously vaccinated with killed measles vaccine; vaccinated with unknown type of measles vaccine during 1963-67; international travelers

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Pediatric Dosing & Uses

Immunization Against Measles, Mumps & Rubella

>12 months old: 0.5 mL SC; administer second dose by 11th or 12th birthday

Inject SC into outer aspect of upper arm

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Drug Interactions

Interaction Checker

measles mumps and rubella vaccine, live and

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    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

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            Adverse Effects

            Suspected adverse events after administration of any vaccine may be reported to Vaccine Adverse Events Reporting System (VAERS), 1-800-822-7967

            Frequency Not Defined

            Fever

            Syncope

            Pain at site

            Headache

            Rash

            Lymphadenopathy

            Myalgia

            Stevens-Johnson syndrome

            Thrombocytopenia

            Optic neuritis

            Encephalitis

            Malaise

            Irritability

            Guillain-Barre synd

            Subacute sclerosing panencephalitis (rare)

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            Contraindications & Cautions

            Contraindications

            Allergy to neomycin or gelatin

            Pregnancy

            HIV: CD4+ count <200 cells/ mcL

            Other immunocompromised conditions (excl medication & radiation)

            Cautions

            Avoid pregnancy for 3 mth after vaccination

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            View Category Definitions

            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: not known if excreted in breast milk

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Duration: Not established

            These products convey active immunity via stimulation of production of endogenously produced antibodies

            The onset of protection from disease is relatively slow, but duration is long lasting (years)

            Pharmacogenomics

            HLA-B7, HLA-B51, HLA-DRB1*13, and HLADQA1*01 is associated with a measles vaccine response

            Homozygosity at HLA-B, HLA-DR, and HLA-DQA1 has been associated with a measles vaccine nonresponse

            Mechanism of Action

            Live, attenuated viruses stimulate active immunity

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            Pricing & Images

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