manganese (OTC)

Brand and Other Names:MnCl2
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 10mg (elemental)
  • 15mg (elemental)
  • 93mg (aspartate; 25mg elemental)
  • 50mg (gluconate; 5.7mg elemental)

capsule

  • 16.67mg

injectable solution

  • 0.1mg/mL
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Adequate Intake

Male: 1.9-2.3 mg/day

Female: 1.6-1.8 mg/day

Pregnancy: 2 mg/day

Lactation: 2.6 mg/day

Prevention of Deficiency

Parenteral solution (TPN):150-800 mcg/day IV

Osteoporosis (Off-label)

5 mg PO qDay

Dosage Forms & Strengths

injectable solution: MnCl2

  • 0.1mg/mL
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Adequate Intake

<6 months: 0.3-0.6 mg/day

6-12 months: 0.6-1.0 mg/day

1-3 years: 1.0-1.5 mg/day

3-8 years: 1.5-2.0 mg/day

8-13 years: 1.9 mg/day (males); 1.6 mg/day (females)

13-18 years: 2.2 mg/day (males); 1.6 mg/day (females)

Prevention of Deficiency

Parenteral solution (TPN): 2-10 mcg/kg/day IV 

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Interactions

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and manganese

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    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Not well documented

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            Warnings

            Contraindications

            Direct IV/IM injection administration (must dilute)

            Cautions

            May cause tissue damage if administered IV or IM directly due to very acidic solution (pH 2.0)

            Injection contains aluminum; use caution in renal impairment and premature infants

            Use caution in liver/biliary tract dysfunction, renal impairment (may need to decrease or withhold dose)

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            Pregnancy & Lactation

            Pregnancy Category: inj: C

            Lactation: Use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Nutrition

            Sources

            Pineapples, almonds, oatmeal, chocolate, pumpkin seeds, whole wheat pasta, pecans, spinach

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            Pharmacology

            Mechanism of Action

            Cofactor in many enzymes, incl superoxide dismutase (SOD, an antioxidant)

            Necessary for glycemic control, energy metabolism, thyroid hormone function

            May enhance bone turnover, cartilage synthesis

            Pharmacokinetics

            Absorption: Poor

            Distribution: Mitochondria of kidney, liver, pituitary gland, and bone

            Excretion: Bile (primarily); urine (negligible)

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            Administration

            IV Info

            Dilute in at least 100 mL (do NOT use undiluted)

            Use promptly after mixing & in a single operation

            No preservatives-discard unused portion

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