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bisoprolol (Rx)Brand and Other Names:Monocor, Zebeta

 
 
 

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

tablet

  • 5mg
  • 10mg
more...

Hypertension

2.5-20 mg PO qDay

Heart Failure

1.25 mg PO qDay; not to exceed 10 mg/day

Renal Impairment

<40 mL/minute: 2.5 mg/day initially; titrate slowly and monitor

Other Information

Less effective than thiazide diuretics in black and geriatric patients

Shown to decrease mortality in hypertension and post-myocardial infarction

Other Indications & Uses

Off-label: angina, SVT, PVC

Safety & efficacy not established

Hypertension

2.5-20 mg PO qDay

Heart Failure

1.25 mg PO qDay; not to exceed 10 mg/day

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Interactions

Interaction Checker

bisoprolol and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            1-10%

            Dizziness (10%)

            Dyssomnia (8%-10%)

            Bradyarrhythmia (9%)

            Upper respiratory infection (5%)

            Diarrhea (4%)

            Rhinitis (4%)

            Arthralgia (3%)

            Cough (3%)

            Dyspnea (2%)

            Nausea (2%)

            Pharyngitis (2%)

            Sinusitis (2%)

            Vomiting (2%)

            <1%

            Cold extremities

            Hypotension

            Depression

            Dyspepsia

            Bronchospasm

            Frequency Not Defined

            Aggravate CHF

            Decrease HDL

            Hypertriglyceridemia

            Mask symptoms of hypoglycemia

            Decreased exercise tolerance

            Raynaud's phenomenon

            May increase triglyceride levels and insulin resistance

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            Warnings

            Contraindications

            Sinus bradycardia, 2°/3° heart block, cardiogenic shock, overt cardiac failure, hypersensitivity, sick sinus syndrome without permanent pacemaker

            Cautions

            Anesthesia/surgery (myocardial depression), bronchospastic disease, cerebrovascular insufficiency, CHF, cardiomegaly, DM, hyperthyroidism/thyrotoxicosis, liver disease, renal impairment, peripheral vascular disease, use in pheochromocytoma, IDDM

            Chronically administered beta-blocking therapy should not be routinely withdrawn prior to major surgery; however, the impaired ability of the heart to respond to reflex adrenergic stimuli may augment the risks of general anesthesia and surgical procedures

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: excretion in milk unknown; use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Mechanism of Action

            Blocks response to beta-adrenergic stimulation; cardioselective for beta-1 at low doses with little or no effect on beta-2 receptors.

            Pharmacikinetics

            Half-Life: 9-12 hr (normal renal function); 27-36hr (<40 mL/min); 8-22 hr (hepatic cirrhosis)

            Peak Plasma Time: 2-4 hr

            Bioavailability: 80%

            Onset of action: 1-2 hr

            Metabolism: Hepatic

            Protein Bound: 30%

            Excretion: half renal, half non-renal

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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