guaifenesin/pseudoephedrine (OTC)

Brand and Other Names:Mucinex D, Guaifenex PSE, more...Refenesen Plus, Sinutab Non-Drying, Congestac
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

guaifenesin/pseudoephedrine

caplet

  • 400mg/60mg

tablet

  • 400mg/20mg
  • 400mg/30mg
  • 400mg/40mg
  • 400mg/60mg

tablet extended release

  • 1200mg/120mg
  • 600mg/60mg
more...

Nasal Congestion, Loosening of Phlegm & Thin Bronchial Secretions

Musinex –D 600/60: 1-2 tab or cap PO q12hr; not to exceed 4 tab or cap/24hr

Musinex –D 1200/120: 1 tab or cap PO q12hr; not to exceed 2 tab or cap/24 hr

Congestac: 1 caplet PO q4-6hr; not to exceed 4 caplets/24hr

Maxifed G: 1-2 tap PO q12hr; not to exceed 4 tab/24hr

Maxifed: 1-1½ tab PO q12hr; not to exceed 3 tab/24hr

Dosage Forms & Strengths

guaifenesin/pseudoephedrine

caplet

  • 400mg/60mg

tablet

  • 400mg/20mg
  • 400mg/30mg
  • 400mg/40mg
  • 400mg/60mg

tablet extended release

  • 1200mg/120mg
  • 600mg/60mg
more...

Nasal Congestion, Loosening of Phlegm & Thin Bronchial Secretions

<6 years

  • Ask a pediatrician

6-12 Years

  • Ambifed G, Maxifed: ½ tab or cap PO q12hr; not to exceed 1 tab or cap/24hr
  • Congestac: ½ caplet PO q4-6hr; not to exceed 2 caplets/24hr
  • Maxifed-G: ½ - 1 tab PO q12hr; not to exceed 2 tab/24hr

>12 Years

  • Musinex –D 600/60: 1-2 tab or cap PO q12hr; not to exceed 4 tab or cap/24hr
  • Musinex –D 1200/120: 1 tab or cap PO q12hr; not to exceed 2 tab or cap/24 hr
  • Congestac: 1 caplet PO q4-6hr; not to exceed 4 caplets/24hr
  • Maxifed G: 1-2 tap PO q12hr; not to exceed 4 tab/24hr
  • Maxifed: 1-1½ tab PO q12hr; not to exceed 3 tab/24hr
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Interactions

Interaction Checker

and guaifenesin/pseudoephedrine

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     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Arrhythmia

            Palpitations

            Convulsion

            Dizziness

            Drowsiness

            Excitability

            Headache

            Tremor

            Weakness

            Nausea

            Vomiting

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            Warnings

            Contraindications

            Contraindicated in documented hypersensitivity to either drug or components

            Within 14 days of MAO inhibitor therapy

            Cautions

            Caution in cardiovascular disease, diabetes mellitus, prostatic hypertrophy and increased intraocular pressure when taking pseudoephedrine

            Guaifenesin is not for administration in persistent cough associated with chronic bronchitis, smoking, asthma, or accompanied with excessive secretions

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            Pregnancy & Lactation

            Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Guaifenesin increases respiratory tract fluid secretions and helps to loosen phlegm and bronchial secretions

            Pseudoephedrine stimulates the alpha-adrenergic receptors causing bronchodilation and vasoconstriction

            Pharmacokinetics

            Guaifenesin

            • Half-Life: 1 hr
            • Onset: 30 min
            • Duration: 4-6 hr
            • Metabolism: Liver
            • Metabolite: b-(2-methoxyphenoxy) lactic acid
            • Excretion: Urine

            Pseudoephedrine

            • Half-Life: 3 hr (children); 9-16 hr (adults)
            • Onset: 30 min (decongestant)
            • Duration: 3-8 hr  
            • Peak Plasma Time: 1.97 hr
            • Concentration: 422 ng/mL
            • Metabolism: Liver, by N-demethylation
            • Metabolites: Inactive
            • Clearance: 7.3-7.6 mL/min/kg
            • Excretion: Urine (43-96%)
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            Images

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