dextromethorphan/guaifenesin (OTC)

Brand and Other Names:Mucinex DM, Robitussin Peak Cold Cough+Chest Congestion DM, more...Delsym Cough + Chest Congestion, Children's Delsym Cough + Chest Congestion, Robitussin Peak Cold Maximum Strength Cough+Chest Congestion DM, Vicks 44E, Coricidin HBP Chest Congestion & Cough, Diabetic Tussin DM, Diabetic Tussin DM Maximum Strength, Duratuss DM, Genatuss DM, Guaicon DM, Guaifenex DM, Guiatuss DM, Mucinex Fast-Max DM Max, Phanatuss DM, Q-Tussin DM, Robafen DM, Safetussin DM, Siltussin DM, St. Joseph Chest Congestion & Cough, Touro DM, Vicks Pediatric Formula 44E
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

dextromethorphan/guaifenesin

capsule

  • 10mg/200mg

granules

  • (5mg/100mg)/packet

liquid

  • (5mg/100mg)/5mL
  • (10mg/100mg)/5mL
  • (10mg/150mg)/5mL
  • (10mg/200mg)/5mL
  • (15mg/100mg)/5mL
  • (15mg/200mg)/5mL
  • (20mg/200mg)/5mL
  • (20mg/300mg)/5mL

liquid oral drops

  • (5mg/100mg)/2.5mL

caplet

  • 15mg/400mg
  • 20mg/400mg

tablet

  • 60mg/1000mg
  • 60mg/1200mg

tablet, extended-release

  • 30mg/600mg
  • 60mg/1200mg

tablet, timed release

  • 60mg/1200mg

tablet, sustained-release

  • 60mg/1200mg
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Cough

Indicated for temporary control of cough due to minor throat and bronchial irritation

General Guidelines: 200-400 mg guaifenesin and 10-20 mg dextromethorphan q4hr; not to exceed 2400 mg guaifenesin and 120 mg dextromethorphan

Mucinex DM: 1-2 tablets q12hr; not to exceed 4 tablets/24 hours

Robitussin Peak Cold Cough+Chest Congestion DM: 10 mL PO q4hr; not to exceed 6 doses/24 hours

Robitussin Peak Cold Maximum Strength Cough+Chest Congestion DM: 10 mL PO q4hr; not to exceed 6 doses/24 hr

Vicks 44E: 15 mL PO q4hr; not to exceed 6 doses/24 hours

Vicks Pediatric Formula 44E: 30 mL PO q4hr; not to exceed 6 doses/24 hours

Safe Tussin DM: 10 mL PO q4hr prn (10 mg/100 mg per 5 mL)

Dosage Forms & Strengths

dextromethorphan/guaifenesin

capsule

  • 10mg/200mg

granules

  • (5mg/100mg)/packet

liquid

  • (5mg/100mg)/5mL
  • (10mg/100mg)/5mL
  • (10mg/150mg)/5mL
  • (10mg/200mg)/5mL
  • (15mg/100mg)/5mL
  • (15mg/200mg)/5mL
  • (20mg/200mg)/5mL

liquid oral drops

  • (5mg/100mg)/2.5mL

caplet

  • 15mg/400mg20mg/400mg

tablet

  • 20mg/400mg

tablet, extended-release

  • 30mg/500mg
  • 30mg/575mg
  • 30mg/600mg
  • 60mg/1000mg

tablet, long-acting

  • 30mg/500mg
  • 30mg/650mg
  • 50mg/1000mg
  • 60mg/1000mg

tablet, sustained-release

  • 30mg/800mg
  • 55mg/1000mg
  • 60mg/1000mg
  • 60mg/1200mg
more...

Cough

Indicated for temporary control of cough due to minor throat and bronchial irritation

<6 years

  • Ask a pediatrician

6-12 years

  • Guifenex DM, Touro DM: 1 tablet PO q12hr; not to exceed 2 tablets/24 hours
  • Robitussin DM, Robitussin Sugar Free Cough: 5 mL PO q4hr; not to exceed 6 doses/24 hours
  • Vicks 44E 7.5 mL q4hr; maximum 6 doses/24 hours
  • Vicks Pediatric Formula 44E: 15 mL PO q4hr; not to exceed 6 doses/24 hours

>12 years

  • Guaifenex DM, Mucinex DM, Touro DM: 1-2 tablets q12hr; not to exceed 4 tablets/24 hours
  • Robitussin Peak Cold Cough+Chest Congestion DM: 10 mL PO q4hr; not to exceed 6 doses/24 hr
  • Robitussin Peak Cold Maximum Strength Cough+Chest Congestion DM: 10 mL PO q4hr; not to exceed 6 doses/24 hr
  • Vicks 44E: 15 mL PO q4hr; not to exceed 6 doses/24 hours
  • Vicks Pediatric Formula 44E: 30 mL PO q4hr; not to exceed 6 doses/24 hours
  • Safetussin DM: 10 mL PO q4hr prn (10 mg/100 mg per 5 mL)
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Interactions

Interaction Checker

and dextromethorphan/guaifenesin

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    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Dizziness

            Drowsiness

            Headache

            Nausea

            Vomiting

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            Warnings

            Contraindications

            Both drugs contraindicated in documented hypersensitivity to either drug or components

            Not for persistent cough associated with chronic bronchitis, smoking, asthma, or accompanied with excessive secretions

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            Pregnancy & Lactation

            Pregnacy Category: C

            Lactation: excretion in milk unknown; use with caution

            Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Guaifenesin increases respiratory tract fluid secretions and helps to loosen phlegm and bronchial secretions.

            Dextromethorphan is a cough suppressant that acts centrally on the cough center in the medulla.

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            Images

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