guaifenesin (OTC)

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Brand and Other Names:Mucinex, Bidex 400, more...Organidin NR

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 200mg
  • 400mg

tablet, extended-release

  • 600mg
  • 1200mg

oral syrup

  • 100mg/5mL

liquid

  • 100mg/5mL
  • 200mg/5mL

packet

  • 50mg
  • 100mg
more...

Cough

100-400 mg PO q4hr; not to exceed 2.4 g/day

Extended release: 1-2 tablets (600-1200 mg) PO q12hr; not to exceed 4 tablets/24 hr (2.4 g/day)

Administration

Swallow extended-release tablets whole; do not chew or crush

Dosage Forms & Strengths

tablet

  • 200mg
  • 400mg

tablet, extended-release

  • 600mg
  • 1200mg

oral syrup

  • 100mg/5mL

liquid

  • 100mg/5mL
  • 200mg/5mL

packet

  • 50mg
  • 100mg
more...

Cough

6 months to 2 years: 25-50 mg q4hr; not to exceed 300 mg/day

2-6 years: 50-100 mg PO q4hr; not to exceed 600 mg/day

6-12 years: 100-200 mg PO q4hr; not to exceed 1.2 g/day

>12 years

  • 100-400 mg PO q4hr; not to exceed 2.4 g/day, OR
  • 1-2 extended-release tablets (600-1200 mg) PO q12hr; not to exceed 4 tablets/24 hr (2.4 g/day)
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Adverse Effects

Frequency Not Defined

Dizziness

Drowsiness

Decreased uric acid levels

Stomach pain

Nausea

Vomiting

Headache

Rash

Postmarketing Reports

Kidney stone formation

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Warnings

Contraindications

Hypersensitivity

Cautions

Often comes in combos; check brand name/other constituents

Some products may contain phenylalanine

When using as self-medication in chronic or persistent coughs, notify health-care practitioner if no improvement within 7 days

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Pregnancy & Lactation

Pregnancy category: C

Lactation: Excretion in milk unknown; use with caution

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Mechanism of Action

Reduces viscosity of secretions by increasing amount of respiratory tract fluid and irritates gastric mucosa

Absorption

Onset: 30 min

Duration: 4-6 hr

Metabolism

Liver

Metabolite: b-(2-methoxyphenoxy) lactic acid

Elimination

Half-life: 1 hr

Excretion: Urine

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