scopolamine/phenylephrine (Discontinued)

Brand and Other Names:Murocoll-2
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

scopolamine/phenylephrine

ophthalmic solution

  • 0.3%/10%
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Mydriasis

1-2 gtt in the conjunctival sac

Repeat in 5 minutes, if necessary

Postoperative Use

For cycloplegia and to break posterior synechiae in iritis

Postoperatively instill 1-2 gtt into eye(s) TID-QID when desirable to maintain dilation and rest ciliary body

Other Information

Combinations induce mydriasis that is considerably greater than that of either drug alone

<18 safety and efficacy not established

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Interactions

Interaction Checker

and scopolamine/phenylephrine

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Headache or browache

            Reactive hyperemia

            Blurred vision

            Sensitivity to light

            Transient burning or stinging

            Transient keratitis

            Hypersensitivity reactions such as allergic conjunctivitis or dermatitis

            Rare (Systemic)

            Hypertension

            Increased perspiration

            Occipital headache

            Pallor or blanching

            Tachycardia

            Trembling or tremors

            Palpitation

            Premature ventricular contractions

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            Warnings

            Contraindications

            Aneurysm

            Hypersensitivity to either component

            Known or suspected angle-closure glaucoma

            Soft contact lenses

            Cautions

            Reduce dose if used within 21 d of MAO inhibitors or TCAs

            Wait 5 minutes between multiple drops (no >3 drops needed)

            May cause false-normal tonometry readings, tonometry should be performed before phenylephrine is administered

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: unknown if excreted in breast milk, use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Onset: 15 min

            Absorption: some systemic

            Maximum effect: 60 min

            Duration: 3 hr

            Recovery (usual): 3-7 hr

            Mechanism of Action

            Phenylephrine acts directly on alpha-adrenergic receptors in eye producing contraction of dilator muscle of pupil and constriction of arterioles in conjunctiva

            Ophthalmic scopolamine blocks the responses of iris sphincter muscle and the accommodative muscle of the ciliary body to cholinergic stimulation, thereby producing mydriasis and cycloplegia

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