Brand and Other Names:Mylanta, Mygel, more...DiGel, Gelusil, Rulox
- Classes: Antacids, Combos
Dosing & Uses
Dosage Forms & Strengths
aluminum hydroxide/magnesium hydroxide/simethicone
- 200mg/200mg/25mg (Gelusil)
Dyspepsia, Abdominal Bloating
10-20 mL PO q4-6hr taken 1 hour before or 3 hours after meals, OR
Chew 2-4 tablets q4-6hr; not to exceed 12 tablets/24 hr
Safety & efficacy not established
Serious - Use Alternative
Significant - Monitor Closely
Frequency Not Defined
- Chalky taste
- Fecal impaction
- Stomach cramps
- Rebound hyperacidity
- Aluminum intoxication
- Milk-alkali syndrome
- Loose stools
Hypersensitivity to any component of the formulation
Caution in renal failure
May increase or decrease rate &/or degree of absorption of concomitantly administered oral drugs by changing GI transit time or by binding the drug
Similar Trade Names may have different compositions
Do not use combination product for hyperphosphatemia
Pregnancy & Lactation
Pregnancy Category: C
Lactation: excretion in milk unknown
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Aluminum hydroxide: Neutralizes stomach hydrocloride to form AlCl3 salt plus water; increases gastric pH
Magnesium hydroxide: Promotes bowel evacuation by causing osmotic retention of fluid, which causes the colon to distend with increased peristaltic activity; forms magnesium chloride when reacts with hydrochloric acid
Simethicone: Disperses and prevents gas pockets in the GI system by decreasing surface tension of gas bubles
- Aluminium hydroxide: Absorbed Al ions are eliminated in the urine (0.1-0.5 mg of Al in aluminum-containing antacid is absorbed from standard daily doses of antacid), Insoluble or poorly absorbed Al salts in the intestines are excreted in feces
- Magnesium hydroxide: absorbed Mg ions (up to 30%) are eliminated in urine, unabsorbed drug is excreted in feces