ambenonium (Discontinued)

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Brand and Other Names:Mytelase

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 10mg
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Myasthenia Gravis

Discontinued by manufacturer (6/25/2012)

Initial: 5 mg PO q6-8hr

Maintenance: 15-100 mg/day, usual 40 mg/day

Up to 50-75 mg PO q6-8hr used

Dosage Forms & Strengths

tablet

  • 10mg
more...

Myasthenia Gravis

Discontinued by manufacturer (6/25/2012)

Initial: 0.3 mg/kg/day divided q6-8hr PO 

Maintenance: 1.5 mg/kg/day divided q6-8hr PO

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Interactions

Interaction Checker

and ambenonium

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Urinary urgency

            Salivation

            Vomiting

            Nausea

            Diarrhea

            Lacrimation, miosis

            Increased bronchial secretions

            Increased diaphoresis

            Urinary urgency

            Muscle cramps

            Fasciculations

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            Warnings

            Contraindications

            Hypersensitivity

            Mechanical obstruction of intestinal or urinary tracts

            Concurrent administration with belladona derivatives or ganglionic blocking agents such as mecamylamine

            Cautions

            May develop anticholinergic insensitivity (withhold or reduce dosages until the patient becomes sensitive again

            Use caution in patients intestinal obstruction, asthma, urinary tract obstruction, or Parkinson's disease

            Narrow therapeutic index may increase risk of overdosage

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Excretion in milk unknown/not recommended

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Acetylcholinesterase inhibitor; prevents hydrolysis of acetylcholine and increases its concentration at transmission sites in parasympathetic neurons and skeletal muscles

            Absorption

            Poor oral absorption

            Onset: 20-30 min

            Duration: 4-8 hr

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