naftifine (Rx)Brand and Other Names:Naftin

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

topical cream

  • 1%
  • 2%

topical gel

  • 1%
  • 2%
more...

Dermatophytoses

1% cream or gel: Apply BID to the affected areas plus a 0.5-inch margin of healthy surrounding skin for 4 weeks

2% cream or gel: Apply qDay to the affected areas plus a 0.5-inch margin of healthy surrounding skin for 2 weeks

Indications

  • 1% cream: Indicated for treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organism Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum
  • 1% gel: Indicated for treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organism Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton Tonsurans, and Epidermophyton floccosum
  • 2% cream or gel: Indicated for treatment of interdigital tinea pedis, tinea cruris, and tinea corporis caused by the organism Trichophyton rubrum

Dosage Forms & Strengths

topical cream

  • 2%

topical gel

  • 2%
more...

Tinea Pedis

2% cream or gel: Indicated for treatment of interdigital tinea pedis caused by the organism Trichophyton rubrum

<12 years: Safety and efficacy not established

12-17 years

  • Use 2% cream or gel
  • Apply cream or gel qDay to the affected areas plus a 0.5-inch margin of healthy surrounding skin for 2 weeks

Tinea Corporis & Tinea Cruris

Indicated for treatment of tinea cruris or tinea corporis caused by the organism Trichophyton rubrum

<12 years: Safety and efficacy not established

12-17 years

  • Use 2% cream
  • Apply cream qDay to the affected areas plus a 0.5-inch margin of healthy surrounding skin for 2 weeks
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Adverse Effects

1-10%

Transient burning/stinging (5-6%)

Skin tenderness (0.5-3%)

Dryness

Erythema

Pruritus

Local irritation

Rash

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Warnings

Contraindications

Hypersensitivity

Cautions

Avoid use of occlusive dressings or wrappings

Keep the cream away from eyes, nose, mouth, & other mucous membranes

Reevaluate dx if no improvement after 4 wk

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Pregnancy & Lactation

Pregnancy Category: B

Lactation: not known whether excreted in breast milk; use caution

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

more...
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Pharmacology

Mechanism of Action

Interferes with sterol biosynthesis by inhibiting squalene monooxygenase (squalene 2,3-epoxidase)

Absorption

3-6%

Metabolism

Liver

Elimination

Excretion: 40-60% urine; 40-60% feces

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Images

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Formulary

FormularyPatient Discounts

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Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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