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spinosad (Rx)Brand and Other Names:Natroba

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

suspension, topical

  • 0.9%
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Lice

Apply suspension to dry scalp and hair using only the amount needed to cover the scalp and hair, after 10 minutes, rinse off with warm water

May repeat if live lice are seen 7 days after first treatment

Administration

Does not require combing and nit removal

For topical use only

Shake bottle well before application

Dosage Forms & Strengths

suspension, topical

  • 0.9%
more...

Lice

<6 months

  • Do not use
  • See benzyl alcohol warning in neonates and infants

≥6 months

  • Apply suspension to dry scalp and hair using only the amount needed to cover the scalp and hair, after 10 minutes, rinse off with warm water
  • May repeat if live lice are seen 7 days after first treatment

Administration

Does not require combing and nit removal

For topical use only

Shake bottle well before application

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Adverse Effects

1-10%

Application site erythema (3%)

Ocular erythema (2%)

Ocular hyperemia (2%)

Application site irritation (1%)

<1%

Application site dryness

Application site exfoliation

Alopecia

Dry skin

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Warnings

Contraindications

Hypersensitivity

Cautions

Contains benzyl alcohol; toxicity and deaths reported in neonates and infants below the age of 6 months with systemic exposure to benzyl alcohol (ie, neonatal gasping syndrome)

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Pregnancy & Lactation

Pregnancy Category: B; low systemic exposure

Lactation: Active ingredient (spinosad) is not distributed in breast milk; however, caution advised because the benzyl alcohol component may be systemically absorbed; lactating women may choose to pump and discard breast milk for 8 hr (5 half-lives of benzyl alcohol) following application

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Mechanism of Action

Causes neuronal excitation in insects, followed by hyperexcitation, paralysis, and death

Pharmacokinetics

Absorption: Not absorbed topically

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Images

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Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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