sodium citrate/dextrose/fructose (OTC)

Brand and Other Names:Nauzene
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

sodium citrate/dextrose/fructose

tablet, chewable

  • 230mg/968mg/175mg

oral solution

  • (0.921g/4.35g/4.17g)/15mL
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Nausea

Indicated for relief of nausea associated with upset stomach, including that due to overindulgence in food and drink

Chew 2-4 tablets completely; may repeat after 15 minutes if needed

Not to exceed 6 doses/24 hr

<18 years: Safety and efficacy not established

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Warnings

Contraindications

Hereditary fructose intolerance

Cautions

Phenylketonurics; contains phenylalanine 4.5 mg/tablet

Diabetes; product contains sugar

Antacids may alter gastric pH and interfere with absorption of some concurrent medications

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: Unknown whether distributed in breast milk

Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Mechanism of Action

Citric acid: Antacid; forms sodium citrate which neutralizes stomach acid

Dextrose and fructose: Hyperosmolar carbohydrate solutions have a direct effect on the GI tract wall, resulting in reduced GI smooth muscle contraction

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