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thiothixene (Rx)Brand and Other Names:Navane

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

capsule

  • 1mg
  • 2mg
  • 5mg
  • 10mg
more...

Schizophrenia

Mild-Moderate: initial: 2 mg PO q8hr; may increase to 15 mg/day

Severe: initial 5 mg PO q12hr

Maintenance: 20-30 mg/day; no more than 60 mg/day PO divided q8-12hr

Dosage Forms & Strengths

capsule

  • 1mg
  • 2mg
  • 5mg
  • 10mg
more...

Schizophrenia

<12 years

  • Not recommended

>12 years

  • Mild-Moderate: initial: 2 mg PO q8hr; may increase to 15 mg/day
  • Severe: initial 5 mg PO q12hr
  • Maintenance: 20-30 mg/day; no more than 60 mg/day PO divided q8-12hr
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Interactions

Interaction Checker

thiothixene and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Constipation

            Decr sweating

            Drowsiness

            EPS ( muscle stiffness, dystonia, Parkinsonism, tardive dyskinesia, akathisia) (60%)

            Incr appetite

            Orthostatic hypotension

            Photosensitivity

            Wt gain

            Xerostomia

            Agitation

            Allergic dermatitis

            Allergic reactions

            Anorexia

            Anticholinergic effects

            Anxiety

            Cerebral edema

            Depression

            Dizziness

            Erectile dysfunction

            Euphoria

            Headache

            Ileus

            Insomnia

            Irregular menses

            Lens opacities (prolonged use)

            Poikilothermia

            Rash

            Restlessness

            Sedation

            Tachycardia

            Weakness

            Agranulocytosis, blood dyscrasias (rare)

            Galactorrhea (rare)

            Heat stroke (rare)

            NMS (infrequent but serious)

            Obstructive hyperbilirubinemia (rare)

            Cholestatic jaundice

            Confusion

            Decr gag reflex

            Gynecomastia

            Hyperpyrexia

            Peripheral edema

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            Warnings

            Black Box Warnings

            Patients with dementia-related psychosis who are treated with antipsychotic drugs are at an increased risk of death as shown in short-term controlled trials. The deaths appeared to be either cardiovascular (eg, heart failure, sudden death) or infectious (eg, pneumonia) in nature.

            This drug is not approved for the treatment of patients with dementia-related psychosis.

            Contraindications

            Documented hypersensitivity

            Blood dyscrasias

            Coma

            Circulatory collapse

            CNS depression (including coma)

            Neuroleptic malignant syndrome (NMS)

            Poorly controlled seizure disorder

            Breastfeeding

            Cautions

            Alcohol withdrawal, cardiovascular disease, glaucoma, BPH, history of seizure disorder, Parkinsonism, urinary retention, liver disease

            Potential cross sensitivity between thioxanthenes & phenothiazine derivatives

            FDA Warning regarding off-label use for dementia in elderly

            Leukopenia/neutropenia and agranulocytosis reported; possible risk factors for leukopenia/neutropenia include pre-existing low white blood cell count (WBC) and history of drug-induced leukopenia/neutropenia

            If history of clinically significant low WBC or drug-induced leukopenia/neutropenia, monitor complete blood count (CBC) frequently during first few months of therapy; discontinue drug at first sign of a clinically significant decline <1000/mm³ in WBC in absence of other causative factors and continue monitoring WBC until recovery

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            Pregnancy & Lactation

            Pregnancy Category: C

            Neonates exposed to antipsychotic drugs during the 3rd trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms following delivery

            These complications vary in severity; in some cases, symptoms have been self-limited, while in other cases neonates have required intensive care unit support and prolonged hospitalization

            Lactation: may be excreted in breast milk; not advised

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Thioxanthene; dopamine D2 receptor antagonist; may also have anticholinergic and alpha-blocking effects

            Pharmacokinetics

            Half-life elimination: 24 hr

            Metabolism: Liver (CYP1A2)

            Protein bound: 90%

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            Images

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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