salicylic acid acne (OTC)

Brand and Other Names:Neutrogena Body Clear Body Wash, Neutrogena Oil-Free Acne Wash, more...Neutrogena Oil-Free Acne Stress Control, Neutrogena Oil-Free Acne Wash Foam Cleanser, Neutrogena Rapid Clear Acne Defense Face Lotion, Neutrogena Rapid Clear Acne Eliminating Spot Gel, Clean & Clear Advantage 3-in1 Foaming Acne wash, Clean & Clear Deep Cleaning Astringent, Clean & Clear Blackhead Eraser Scrub, Clean & Clear Dual Action Moisturizer, Clean & Clear Advantage Mark Treatment, Clean and Clear Advantage Acne Control Moisturizer, Oxy Clinical Advanced Face Wash, Oxy Maximum Face Scrub, Oxy Maximum Hydrating Body Wash, Oxy Maximum Cleansing Pads, Oxy Clinical Hydrating Therapy, Oxy Clinical Foaming Face Wash, Palmers Skin Success Acne Medication Cleanser, Zapzyt Acne Wash, Zapzyt Pore Clearing Scrub, Clearasil Ultra Rapid Action Face Scrub, Clearasil Daily Clear Daily Pore Cleansing Pads, Clearasil Daily Clear Vanishing Acne Treatment Cream, Benzac Skin Balancing Foaming Cleanser 0.5%, Benzac Intensive Spot Treatment 2%, Benzac Blemish Clearing Hydrator 0.5%, Benzac Skin Refining Mask
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

topical lotion

  • 0.5%

topical cleanser

  • 2%
  • 0.5%

topical toner/astringent

  • 2%

topical gel

  • 2%

topical pads

  • 2%

topical cream

  • 2%
  • 6%

topical foam/aerosol

  • 6%

topical bar soap

  • 2%

topical mask

  • 0.5% plus East Indian sandalwood oil and French clay
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Acne Vulgaris

Cleansers: Twice daily, gently massage cleanser onto wet face & neck until lathered; rinse thoroughly

Scrubs: Once daily, gently massage cleanser onto wet face & neck until lathered; rinse thoroughly

Cream/foam/gel: After cleansing, apply sparingly to affected area(s) up to TID

Pads/Wipes: After cleansing, gently wipe face & neck w/ pad; do not rinse

Shower/bath gels/soap: Use in shower once daily; massage over skin; rinse well

Product content varies, check individual labeling

Dosage Forms & Strengths

topical lotion

  • 0.5%

topical cleanser

  • 0.5%
  • 2%

topical toner/astringent

  • 2%

topical gel

  • 2%

topical pads

  • 2%

topical cream

  • 2%
  • 6%

topical foam/aerosol

  • 6%

topical bar soap

  • 2%

topical mask

  • 0.5% plus East Indian sandalwood oil and French clay
more...

Acne Vulgaris

Adolescents: As adults

Cleansers: Twice daily, gently massage cleanser onto wet face & neck until lathered; rinse thoroughly

Scrubs: Once daily, gently massage cleanser onto wet face & neck until lathered; rinse thoroughly

Cream/foam/gel: After cleansing, apply sparingly to affected area(s) up to TID

Pads/Wipes: After cleansing, gently wipe face & neck w/ pad; do not rinse

Shower/bath gels/soap: Use in shower once daily; massage over skin; rinse well

Product content varies, check individual labeling

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Adverse Effects

Frequency Not Defined

Stinging/burning of skin

Desquamation

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Warnings

Contraindications

Hypersensitivity

Moles

Birthmarks

Eyes

Facial warts or warts on mucous membranes

Warts with hair growing from them

Genitals

Infected, reddened, or irritated areas

Cautions

Topical use only

Avoid contact with eyes

Serious allergic reactions

  • Rare but serious and potentially life-threatening allergic reactions or severe irritation reported
  • Instruct patients to stop using their topical acne product and seek emergency medical attention immediately if they experience hypersensitivity reactions (eg, throat tightness, difficulty breathing, feeling fain, or swelling of the eyes, face, lips, or tongue)
  • Also instruct patients to stop using the product if they develop hives or itching
  • These serious hypersensitivity reactions differ from the local skin irritation that may occur at the product application site (eg, redness, burning, dryness, itching, peeling, or slight swelling)
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Pregnancy & Lactation

Pregnancy category: C

Lactation: unknown

Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Mechanism of Action

Comedolytic agent. Inhibits the formation of comedones resulting from oil and skin cells that become trapped in the pore.

Its lipophilic characteristics facilitate the peeling of the exterior layer of the dermis and opens follicles that are plugged. This leads skin cells to renew their cell cycle of proliferation and differentiation.

Salicylic acid can interfere with the arachidonic acid cascade of the inflammatory process. This action results in the reduction of inflammatory acne lesions.

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Administration

Instructions

Before using a topical acne product for the first time, patients should apply a small amount to 1 or 2 small affected areas of the skin for 3 days, if no discomfort/allergy occurs, then the product can be used according to the directions

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Images

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