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nepafenac ophthalmic (Rx)Brand and Other Names:Nevanac, Ilevro

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

ophthalmic suspension

  • 0.1%
  • 0.3%
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Ocular Pain & Inflammation

Indicated for pain and inflammation associated with cataract surgery

0.1%: 1 gtt TID to affected eye(s) beginning 1 day before cataract surgery, on the day of surgery and through 2 weeks postoperatively

0.3%: 1 gtt once daily beginning 1 day before cataract surgery, on day of surgery, and continue through the first 2 weeks postoperatively; an additional drop should be adminsitered 30-120 minutes before surgery

Administration

Do not wear contact lenses while using

Shake well before using

<10 years old: Safety and efficacy not established

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Adverse Effects

1-10%

Capsular opacity

Decr visual acuity

Foreign body sensation

Increased IOP

Sticky sensation

Conjunctival edema

Corneal edema

Dry eye

Headache

HTN

Lid margin crusting

N/V

Ocular discomfort

Ocular hyperemia

Ocular pain

Ocular pruritus

Photophobia

Tearing

Vitreous detachment

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Warnings

Contraindications

Hypersensitivity to NSAIDs or any ingredients

Cautions

Sensitivity to aspirin or phenylacetic acid deivatives

May cause incr bleeding in ocular tissues

May cause keratitis & corneal damage (risk incr if applied earlier than 1 day presurgery or longer than 2 wk postsurgery)

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: use caution

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Mechanism of Action

Non-steroidal anti-inflammatory prodrug, converted to amfenac which putatively inhibits prostaglandin biosynthesis

Absorption

Absoption: Low systemic absorption

Peak Plasma: nepafenac 0.31 ng/mL; amfenac: 0.42 ng/mL

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Images

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Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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