nicotine inhaled (Rx)

Brand and Other Names:Nicorette Inhaler, Nicotrol Inhaler
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Dosing & Uses

AdultPediatric

Dosage Forms and Strengths

oral inhaler

  • 10mg/cartridge (4 mg delivered)

Smoking Cessation

Indicated to reduce withdrawal symptoms during smoking cessation

Best effect observed with frequent, continuous puffing over 20 minute periods throughout the day

6 or more cartridges/day PRN [4 mg/cartridge]; do not exceed 16 cartridges/day

Use at least 6 cartridges/day for the first 3-6 weeks for improved success at quiting

Administration

Before initiating nicotine replacement reatment, patient must have desire to stop smoking

Most effective as part of comprehensive smoking cessation plan

See product user's guides for details

Not recommended

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Interactions

Interaction Checker

and nicotine inhaled

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Mouth/throat irritation (66%)

            Cough (32%)

            Headache (18-26%)

            Rhinitis (23%)

            Dyspepsia (18%)

            1-10%

            Back pain (6%)

            Arthralgia (5%)

            Flatulence (4%)

            Gum problems (4%)

            Acne (3%)

            Dysmenorrhea (3%)

            <1%

            Nicotine withdrawal (irritability, dizziness, headache, insomnia)

            Hiccups

            N/V

            Anorexia

            Diarrhea

            Increased salivation

            Cardiac dysrhythmia (rare)

            Hypertension (rare)

            Tachyarrhythmia (rare)

            Immune hypersensitivity reaction (rare)

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            Warnings

            Contraindications

            Hypersensitivity to nicotine or components

            Active smokers following the postmyocardial period

            Patients with life-threatening arrhythmias or worsening of angina pectoris if severe

            Nonsmokers

            Cautions

            Not studied in reactive airway disease; may cause bronchospasm

            Caution with hypertension, cardiovascular, or peripheral vascular disease

            Caution with hyperthyroidism, pheochromocytoma, or insulin-dependent diabetes, since nicotine causes the release of catecholamines by the adrenal medulla

            Delays healing of peptic ulcer disease

            Use caution in patients with oropharyngeal inflammation, peptic ulcer, or history of esophagitis

            Caution in severe renal impairment

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            Pregnancy & Lactation

            Pregnancy Category: D

            Lactation: Unknown whether excreted in breast milk; use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Agonist at nicotinic receptors; potent ganglionic and central nervous stimulant

            Absorption

            Peak plasma time: 15 minutes

            Distribution

            Protein binding: <5%

            Vd: 2-3 L/kg

            Metabolism

            Metabolism: liver (some renal, lung)

            Metabolites: over 20, less active

            Elimination

            Clearance: 1.2 L/min

            Excretion: urine (30%)

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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