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orphenadrine (Rx)Brand and Other Names:Norflex

 
 
 

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

injectable solution

  • 30mg/mL

tablet, extended release

  • 100mg
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Muscle Spasm, Relief of Discomfort Associated with Acute Painful Musculoskeletal Conditions

100 mg PO q12hr OR

60 mg IV/IM q12hr (switch to PO as soon as possible)

Other Indications & Uses

Off-label: Leg cramps resistant to quinine, Parkinson's disease

Safety and efficacy not established

Caution; not recommended for use in elderly because of increased sedation and anticholinergic effects

Muscle spasm, relief of discomfort associated with acute painful musculoskeletal conditions

100 mg PO q12hr OR

60 mg IV/IM q12hr (switch to PO as soon as possible)

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Interactions

Interaction Checker

orphenadrine and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Dry mouth

            Urinary retention

            Blurred vision, mydriasis

            Drowsiness

            Headache

            Weakness

            Increased IOP

            Palpitation

            Tachycardia

            GI disturbances

            CNS stimulation (restlessness, agitation, insomnia, mental confusion)

            Lightheadedness

            Dizziness

            Syncope

            Pruritus

            Urticarial rash

            Tremor

            Anaphylactic reactions

            Aplastic anemia

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            Warnings

            Contraindications

            Hypersensitivity

            Narrow-angle glaucoma

            Pyloric/duodenal obstruction, BPH, stenosing peptic ulcers, cardiospasm (mega-esophagus), myasthenia gravis, obstructive uropathy, paralytic ileus, ulcerative colitis, toxic megacolon, achalasia

            Cautions

            Diarrhea, partial obstructive uropathy, open-angle glaucoma, cardiovascular disease, hepatic/renal impairment, cardiac conduction disorder, thyrotoxicosis, history of drug abuse or acute alcoholism

            May cause drowsiness/dizziness

            May take with food to avoid stomach upset

            Injectable form contains sulfites, & precipitates anaphylactic-type reactions in sensitive or asthmatic individuals

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: no data

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Mechanism of Action

            May work through central atropine-like effect; anticholinergic activity in brain stem; has euphorigenic and analgesic properties

            Pharmacokinetics

            Half-life elimination: 14-16 hr

            Onset: 2-4 hr (peak)

            Duration: 4-6 hr

            Metabolism: Liver

            Protein binding: 20%

            Metabolites: Not fully determined (>8 metabolites)

            Excretion: urine (principally)

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            Administration

            IV/IM Administration

            Administer IM or IV injection

            IV may be given undiluted or diluted in SWI

            Give slow IV ~5 min with pt in supine position

            Patient should remain in this position for 5-10 min post-injection

            To minimize adverse reactions after parenteral administration of the drug, patient should be assisted from recumbent position

            Storage

            Store at <40°C, preferably between 15-30°C

            Protect from freezing

            Protect from light; store in tight, light-resistant containers

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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