norgestrel (Discontinued)

Brand and Other Names:Ovrette
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Dosing & Uses

AdultPediatric

No longer available in US

Contraception

0.075 mg PO qDay, at same time each day

Not applicable

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Interactions

Interaction Checker

and norgestrel

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Edema

            Weakness

            Anorexia

            Amenorrhea

            Breakthrough bleeding

            Change in menstrual flow

            Spotting

            Frequency Not Defined

            Deep vein thrombosis

            Thrombophlebitis

            Depression

            Dizziness

            Headache

            Nervousness

            Somnolence

            Breast tenderness

            Galactorrhea

            Abdominal pain

            Nausea

            Vomiting

            Change in weight

            Cholestatic jaundice

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            Warnings

            Contraindications

            Documented hypersensitivity

            Active or history of breast cancer

            Arterial thromboembolic disease (stroke, MI), thrombophlebitis, DVT/PE, thrombogenic valvular disease

            Estrogen-dependent neoplasia

            Liver disease, liver tumors

            Undiagnosed abnormal vaginal bleeding

            Uncontrolled hypertension

            Diabetes mellitus with vascular involvement

            Jaundice with prior oral contraceptive use, pregnancy, smoking >15 cigarettes/d) and >35 yo, history of migraine w/ aura

            Pregnancy or use as a diagnostic test for pregnancy

            Cautions

            Documented hypersensitivity

            Active or history of breast cancer

            Thrombophlebitis, DVT/PE, thrombogenic valvular disease

            Estrogen-dependent neoplasia

            Liver disease, liver tumors

            Undiagnosed abnormal vaginal bleeding, uncontrolled hypertension, diabetes mellitus with vascular involvement, jaundice with prior oral contraceptive use, pregnancy, smoking >15 cigarettes/d) and >35 yo, history of migraine w/ aura

            Serum levels near baseline 24 hr after ingestion, so rigid adherence to dosing schedule is essential for efficacy

            DM, asthma, cardiac dysfunction, irregular menstrual bleeding patterns, bone mineral density changes, depression, epilepsy, migraine, renal dysfunction

            Risk of ectopic pregnancy is 0.5%

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            Pregnancy & Lactation

            Pregnancy Category: X

            Lactation: unsafe

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Peak Plasma Time: 2 hr

            Metabolism: liver

            Metabolites: sulfate and glucuronide metabolites (inactive)

            Mechanism of Action

            Progestin; inhibits secretion of gonadotropins from pituitary gland; prevents ovulation in half of users, thickens cervical mucus to inhibit sperm penetration

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