ofloxacin ophthalmic (Rx)Brand and Other Names:Ocuflox

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

ophthalmic solution

  • 0.3%
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Bacterial Conjunctivitis

Days 1-2: 1-2 gtt in affected eye q2-4hr, THEN

Days 3-7: 1-2 gtt four times daily

Corneal Ulcer

Days 1-2: 1-2 gtt q30min while awake (WA), awaken 4-6 hours after retiring

Days 3-7: 1-2 gtt q1hr while awake

Days 7-9: 1-2 gtt four times daily until clinical cure

Dosage Forms & Strengths

ophthalmic solution

  • 0.3%
more...

Bacterial Conjunctivitis

< 1 year

  • Not recommended

> 1 year

  • Day 1-2: 1-2 gtt in affected eye q2-4hr, THEN
  • Day 3-7: 1-2 gtt four times daily

Corneal Ulcer

< 1 year

  • Not recommended

> 1 year

  • Days 1-2: 1-2 gtt q30min while awake (WA), awaken 4-6 hours after retiring
  • Days 3-7: 1-2 gtt q1hr while awake
  • Days 7-9: 1-2 gtt four times daily until clinical cure
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Adverse Effects

Frequency Not Defined

Transient ocular burning or discomfort following instillation of the solution

Conjunctival hyperemia

Chemical conjunctivitis/keratitis

Foreign body sensation

Blurred vision

Periocular/facial edema

Eye pain

Photophobia

Pruritus

Stinging

Tearing

Dryness

Hemorrhagic conjunctivitis with palpebral edema (rare)

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Warnings

Contraindications

Hypersensitivity to quinolones or other components in product

Cautions

May result in overgrowth of nonsusceptible organisms, including fungi

Careful monitoring, including slit-lamp biomicroscopy and fluorescein staining when appropriate may be necessary

Not for subconjunctival injection

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: Not known if distributed into milk; discontinue breastfeeding or drug

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Mechanism of Action

Bactericidal

Inhibits DNA topoisomerase (ATP-hydrolyzing), a type II DNA topoisomerase commonly referred to as DNA-gyrase, in susceptible organisms

Pharmacokinetics

Absorption: Minimal systemic absorption with ophthalmic use

Excretion: Urine

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Images

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Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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