Brand and Other Names:Osmitrol
- Classes: Diuretics, Osmotic Agents
Dosing & Uses
Dosage Forms & Strengths
Reduction of intracranial pressure and treatment of cerebral edema
Test dose: 200 mg/kg IV infused over 3-5 minutes
Load: 500-1000 mg/kg IV x1 dose
Bronchitol: Facilitates clearance of mucus with bronchiectasis, and in patients with cystic fibrosis at risk for bronchiectasis
Orphan indication sponsor
- Pharmaxis Ltd; 10 Rodborough Rd, NSW 2086, Australia
Do NOT give simultaneously with blood
Use 15-25% solution
Other Indications & Uses
Dosage Forms & Strengths
Discontinue if no diuresis within 2 hr
Treatment of intoxications: Give therapeutic dose as 5 or 10% solution IV PRN
Serious - Use Alternative
Significant - Monitor Closely
Frequency Not Defined
Angina-like chest pains
Hypersensitivity, anuria, severe pulmonary edema or heart failure, severe dehydration, metabolic edema, progressive renal dz, active intracranial bleeding (except during craniotomy)
Do not mix w/ blood
May cause hypovolemia, headache, polydipsia
It might be more effective than pentobarbital, but less effective than hypertonic saline in pt w/acute traumatic brain injury
Pregnancy & Lactation
Pregnancy Category: C
Lactation: use caution
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Half life: 100 min
Diuresis: 1-3 hr after IV administration of mannitol. Lowering of
IOP reduction: 30-60 min
ICP reduction: 15 min
IOP reduction: 4-6 hr
ICP reduction: 3-8 hr
Metabolism: liver (very slight)
Excretion: urine (80%)
Mechanism of Action
Additive: etoposide w/ cisplatin & KCl(?), imipenem-cilastatin (may be used for shorter periods), meropenem (may be used for shorter periods)
Y-site: cefepime, doxorubicin liposomal, filgrastim
Additive (partial list): cefoxitin, cimetidine, furosemide. metoclopramide, ondansetron
Y-site: allopurinol, cisatracurium, etoposide phosphate, linezolid, ondansetron, propofol, vinorelbine
Use administration set with filter for infusion of injections containing 20% or more, since crystals may be present
For transurethral prostatic resection, mannitol irrigation solns are instilled into bladder via indwelling urethral catheter
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