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mannitol (Rx)Brand and Other Names:Osmitrol

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

injectable solution

  • 5%
  • 10%
  • 15%
  • 20%
  • 25%
more...

Cerebral Edema

Reduction of intracranial pressure and treatment of cerebral edema

1.5-2 g/kg IV infused over 30-60 minutes 

Intraocular Pressure

1.5-2 g/kg IV infused over 30-60 minutes 

Anuria/Oliguria

Test dose: 200 mg/kg IV infused over 3-5 minutes

Load: 500-1000 mg/kg IV x1 dose

Maintenance: 250-500 mg/kg IV q4-6hr 

Bronchiectasis (Orphan)

Bronchitol: Facilitates clearance of mucus with bronchiectasis, and in patients with cystic fibrosis at risk for bronchiectasis

Orphan indication sponsor

  • Pharmaxis Ltd; 10 Rodborough Rd, NSW 2086, Australia

Other Information

Do NOT give simultaneously with blood

Use 15-25% solution

Other Indications & Uses

Brain mass

Dosage Forms & Strengths

injectable solution

  • 5%
  • 10%
  • 15%
  • 20%
  • 25%
more...

Edema

0.25-1 g/kg IV initially; maintenance dose of 0.25-0.5 g/kg IV q4-6hr 

Anuria/Oliguria

Test dose: 0.2 g/kg IV over 3-5 minutes; not to exceed 12.5 g 

Discontinue if no diuresis within 2 hr

Other Information

Treatment of intoxications: Give therapeutic dose as 5 or 10% solution IV PRN

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Interactions

Interaction Checker

mannitol and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            Sort by :  
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            Adverse Effects

            Frequency Not Defined

            Angina-like chest pains

            CHF

            Hypotension

            Phlebitis

            Convulsions

            Chills

            Dizziness

            Headache

            Acidosis

            Fluid/electrolyte imbalances

            Thirst

            Nausea

            Vomiting

            Blurred vision

            Urinary retention

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            Warnings

            Contraindications

            Hypersensitivity, anuria, severe pulmonary edema or heart failure, severe dehydration, metabolic edema, progressive renal dz, active intracranial bleeding (except during craniotomy)

            Cautions

            Do not mix w/ blood

            May cause hypovolemia, headache, polydipsia

            It might be more effective than pentobarbital, but less effective than hypertonic saline in pt w/acute traumatic brain injury

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Half life: 100 min

            Onset

            Diuresis: 1-3 hr after IV administration of mannitol. Lowering of

            IOP reduction: 30-60 min

            ICP reduction: 15 min

            Duration

            IOP reduction: 4-6 hr

            ICP reduction: 3-8 hr

            Other Information

            Metabolism: liver (very slight)

            Metabolites: glycogen

            Excretion: urine (80%)

            Mechanism of Action

            Osmotic diuretic

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            Administration

            IV Incompatibilities:

            Additive: etoposide w/ cisplatin & KCl(?), imipenem-cilastatin (may be used for shorter periods), meropenem (may be used for shorter periods)

            Y-site: cefepime, doxorubicin liposomal, filgrastim

            IV Compatibilities

            Additive (partial list): cefoxitin, cimetidine, furosemide. metoclopramide, ondansetron

            Y-site: allopurinol, cisatracurium, etoposide phosphate, linezolid, ondansetron, propofol, vinorelbine

            IV Preparation

            Infusion only

            Use administration set with filter for infusion of injections containing 20% or more, since crystals may be present

            For transurethral prostatic resection, mannitol irrigation solns are instilled into bladder via indwelling urethral catheter

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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