Close
New

Medscape is available in 5 Language Editions – Choose your Edition here.

 

oxandrolone (Rx)Brand and Other Names:Oxandrin

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet: Schedule III

  • 2.5mg
  • 10mg
more...

Bone Pain Due to Osteoporosis

2.5-20 mg/day PO divided q6-12hr for 2-4 weeks

May repeat intermittently PRN

Weight Gain

Promote weight gain after weight loss following extensive surgery, chronic infections or severe trauma, or weight loss due to unknown etiology

2.5-20 mg/day divided q6-12hr PO for 2-4 weeks

May repeat intermittently PRN

Offset Protein Catabolism

Due to prolonged admin corticosteroids or associated with catabolic illness (off-label)

2.5-20 mg/day divided q6-12hr PO for 2-4 weeks

HIV-Wasting Syndrome (Orphan)

Adjunctive therapy for AIDS patients suffering from HIV-wasting syndrome

Orphan indication sponsor

  • Bio-Technology General Corp; One Tower Center Boulevard, 12 th floor; East Brunswick, NJ 08816

Muscular Dystrophy (Orphan)

Treatment of patients with Duchenne's muscular dystrophy and Becker's muscular dystrophy

Orphan indication sponsor

  • Savient Pharmaceuticals, Inc; One Tower Center Boulevard, 12th floor; East Brunswick, NJ 08816

Dosage Forms & Strengths

tablet: Schedule III

  • 2.5mg
  • 10mg
more...

Bone pain

≤ 0.1 mg/kg/day PO; repeat intermitently as indicated 

Protein Catabolism

≤ 0.1 mg/kg/day PO; repeat intermitently as indicated

Weight Gain

≤ 0.1 mg/kg/day PO; repeat intermitently as indicated

Next

Interactions

Interaction Checker

oxandrolone and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            Sort by :  
             activity indicator 
            Previous
            Next

            Adverse Effects

            Frequency Not Defined

            Males

            • Gynecomastia
            • Inhibition of testicular function
            • Impotence
            • Priapism
            • Bladder irritability

            Females

            • Hirsutism
            • Male-pattern baldness
            • Menstrual irregularities
            • Virilism

            Serious

            • Neoplasm of liver, Peliosis hepatis
            • Premature epiphyseal closure, Children

            Edema

            Increased risk of atherosclerosis

            Habituation

            Changes in libido

            Acne

            Retention of electrolytes

            Serum lipid levels

            Cholestatic hepatitis

            Hepatic d/o

            Jaundice

            Previous
            Next

            Warnings

            Black Box Warnings

            Peliosis Hepatis

            • Peliosis hepatitis has been reported with androgenic anabolic steroid therapy In this condition, the liver & sometimes splenic tissue is replaced with blood-filled cysts
            • These cysts sometimes present with minimal hepatic dysfunction but have been associated with liver failure
            • Often not detected until life-threatening liver failure or intra-abdominal hemorrhage develops
            • Discontinuing an anabolic steroid usually results in complete disappearance of lesions

            Liver Cell Tumors

            • Liver cell tumors have been reported
            • Typically, these tumors are benign & androgen-dependent, but fatal malignant tumors have been reported
            • Discontinuing anabolic steroids often result in regression or arrested progression of tumor
            • Important to recognize that hepatic tumors associated w/ androgens or anabolic steroids are much more vascular than other hepatic tumors & may be silent until life-threatening intra-abdominal hemorrhage develops

            Blood Lipid Changes

            • May cause blood lipid changes associated w/ increased risk of atherosclerosis
            • Lipid changes include decreased HDL & sometimes increased LDL; changes may be very marked & could have serious impact on risk for atherosclerosis & coronary artery disease

            Contraindications

            Known or suspected prostate or breast CA in males

            Females: breast cancer with hypercalcemia

            Pregnancy

            Nephrosis or the nephrotic phase of nephritis

            Hypercalcemia

            Cautions

            Increases risk of peliosis hepatis & liver cell tumors has been reported with anabolic steroids

            Risk of cholestatic hepatitis & jaundice - discontinue if cholestatic hepatitis with jaundice appears or LFTS abnormal

            Risk of hypercalcemia in breast CA patients - discontinue if hypercalcemia occurs

            Increases risk of prostatic hypertrophy & prostate CA in geriatric patients

            Concomitant administration with warfarin may require dose reduction of warfarin

            Risk of growth retardation in children

            Concurrent dosing with warfarin may result in unexpectedly high increases in INR & PT

            Risk of edema with or without CHF in patients with preexisting cardiac, renal or liver disease

            Does not improve athletic performance

            Previous
            Next

            Pregnancy & Lactation

            Pregnancy Category: X

            Lactation: Discontinue drug if choosing to breastfeed or do not nurse

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
            Previous
            Next

            Pharmacology

            Mechanism of Action

            Anabolic steroid; promotes body tissue building, increases production of erythropoietin, increases Hgb & RBC volume

            Pharamacokinetics

            Half-life: 10-13 hr

            Previous
            Next

            Images

            Previous
            Next

            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
            Add or Remove Plans
            Plans for
            Select State:
            Non-Medicare PlansMedicare Plans

            Select a box to add or remove a plan.

            Select a class to view formulary status for similar drugs

            Additional Offers
            Email to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Email Forms to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Previous
             
             
             
            All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.