250-750 mg PO BID-QID
Has been used traditionally by South African San Bushmen to suppress appetite
P57, a putative pharmacologically active steroidal glycoside, has been isolated & in clinical trials
In one study, large doses of P57 reduced daily caloric intake by 100 cal by Day 15 in a small number of healthy but overweight subjects
Many weight loss supplements assert they contain Hoodia, but actual amount or efficacy unverified
Causes thirst suppression in addition to appetite suppression
Pregnancy & Lactation
Pregnancy Category: N/A
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Extract of Hoodia gordonii, a South African succulent (not a cactus)
Putative active principle, a steroidal glycoside termed P57, appears to act at the hypothalamic level to shut off hunger signals