carbinoxamine (Rx)

  • Print
Brand and Other Names:Palgic, Arbinoxa, more...Karbinal ER

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

tablet

  • 4mg

oral solution

  • 4mg/5mL

oral suspension, extended-release (Karbinal ER)

  • 4mg/5mL
more...

Allergies

4-8 mg PO q6-8hr PO; not to exceed 24 mg/day

Karbinal ER: 6-16 mg (7.5-20 mL) PO q12hr

Other Indications & Uses

Seasonal & perennial allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis, urticaria & angioedema, dermatographism, anaphylactic reactions adjunctive to epinephrine, amelioration of the severity of allergic reactions to blood or plasma

Dosage Forms & Strengths

tablet

  • 4mg

oral solution

  • 4mg/5mL

oral suspension, extended-release (Karbinal ER)

  • 4mg/5mL
more...

Allergies

2-6 years: 0.2-0.4 mg/kg/day PO divided q6-8hr or 1-2 mg (2.5 mL) PO q6-8hr  

>6 years: 2-4 mg (5-7.5 mL) PO q6-8hr

Karbinal ER

  • 2-3 years: 3-4 mg (3.75-5 mL) PO q12hr
  • 4-5 years: 3-8 mg (3.75-10 mL) PO q12hr
  • 6-11 years: 6-12 mg (7.5-15 mL) PO q12hr
  • ≥12 years: 6-16 mg (7.5-20 mL) PO q12hr

Start at lower end of dosage range (4-8 mg PO q6-8hr) and decrease frequency if needed

Nonanticholinergic antihistamines should be considered first when treating allergic reactions (Beers Criteria)

Avoid use in elderly because of high incidence of anticholinergic effects

Clearance reduced with advanced age, greater risk of confusion, dry mouth, constipation, and other anticholinergic effects and toxicity

May exacerbate existing lower urinary conditions or benign prostatic hyperplasia

Next:

Interactions

Interaction Checker

and carbinoxamine

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 
            Previous
            Next:

            Adverse Effects

            Varies in incidence & severity with the individual drug; also individual patients vary in susceptibility

            Frequency Not Defined

            CNS depression

            Drowsiness

            Sedation ranging from mild drowsiness to deep sleep (most frequent)

            Dizziness

            Lassitude

            Disturbed coordination

            Muscular weakness

            Restlessness, insomnia, tremors, euphoria, nervousness, delirium, palpitation, seizures is less common

            Epigastric distress

            Anorexia

            Nausea

            Vomiting

            Diarrhea

            Constipation

            Cholestasis, hepatitis, hepatic failure, hepatic function abnormality, jaundice is rare

            Tachycardia, palpitation ECG changes (eg, widened QRS)

            Arrhythmias (eg, extrasystole, heart block)

            Hypotension

            Hypertension

            Dizziness, sedation, and hypotension may occur in geriatric patients

            Dryness of mouth, nose, and throat

            Dysuria

            Urinary retention

            Impotence

            Vertigo

            Visual disturbances

            Blurred vision

            Diplopia; tinnitus

            Acute labyrinthitis

            Insomnia

            Tremors

            Nervousness

            Irritability

            Facial dyskinesia

            Tightness of the chest

            Thickening of bronchial secretions

            Wheezing

            Nasal stuffiness

            Sweating

            Chills

            Early menses

            Toxic psychosis

            Headache

            Faintness

            Paresthesia

            Agranulocytosis

            Hemolytic anemia

            Leukopenia

            Thrombocytopenia

            Pancytopenia

            Previous
            Next:

            Warnings

            Contraindications

            Hypersensitivity

            Concurrency with MAO inhibitors

            Preemies & neonates

            Nursing mothers

            Lower respiratory tract symptoms, eg, asthma

            Cautions

            Narrow-angle glaucoma, prostatic hypertrophy, peptic ulcer, GI obstruction, bladder outflow obstruction, history of bronchial asthma, incr IOP, HTN, hyperthyroidism, cardiovascular dz

            May affect mental alertness

            Elderly

            Previous
            Next:

            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: excretion in milk unknown/contraindicated

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
            Previous
            Next:

            Pharmacology

            Mechanism of Action

            Histamine H1-receptor antagonist in blood vessels, respiratory tract, and gastrointestinal tract

            Pharmacokinetics

            Half-Life: 10-20 hr

            Metabolism: Hepatic

            Excretion: Urine

            Previous
            Next:

            Images

            Previous
            Next:

            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
            Additional Offers
            Email to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Email Forms to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Previous