Brand and Other Names:Paludrine
- Classes: Antimalarials
Dosing & Uses
Available in the US/Canada as a combo with atovaquone. Monotherapy info for reference only
400 mg (with 1 g atovaquone) PO qD x3 days
200 mg PO qD, OR
100 mg (with 250 mg atovaquone) PO qD
Other Indications & Uses
Malaria (P. falciparum)
11-20 kg: 100 mg
21-30 kg: 200 mg
31-40 kg: 300 mg
All PO qD x3 days
<2 years old: 50 mg
2-6 years old: 100 mg
7-10 years old: 150 mg
>10 years old: 200 mg
All PO qD
Abdominal pain (33% children)
Headache (22% adults, 19% children)
Increased LFT's (17%)
Myalgia (12% adults)
Abdominal pain (9% adults)
Back pain (8% adults)
Upper respiratory tract infection (8% adults)
Cough (6% adults, 9% children)
Flu-like syndrome (2% adults, 9% children)
Vomiting (1% adults, 7% children)
Diarrhea (6% adults, 2% children)
Fever (5% adults, 6% children)
Dyspepsia (3% adults)
Gastritis (3% adults)
Frequency Not Defined
Hepatitis (rare )
Liver failure (rare)
Anaphylaxis (rare )
Immune hypersensitivity reaction
Erythema multiforme (rare )
Stevens-Johnson syndrome (rare )
Hypersensitivity to proguanil or atovaquone
Avoid during breast-feeding
For acute malaria, admin atovaquone concomitantly
For malaria prevention, admin chloroquine phosphate or atovaquone concomitantly
Pregnancy & Lactation
Pregnancy Category: unknown
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.
|1||This drug is available at the lowest co-pay. Most commonly, these are generic drugs.|
|2||This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.|
|3||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.|
|4||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|5||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|6||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|NC||NOT COVERED – Drugs that are not covered by the plan.|
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