acetaminophen/magnesium salicylate/pamabrom (OTC)

Brand and Other Names:Pamprin Cramp
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

acetaminophen/magnesium salicylate/pamabrom

caplet

  • 250mg/250mg/25mg
more...

Menstrual Symptoms

Indicated for relief of symptoms associated with menstrual periods including cramps, headaches, backaches, water-weight gain, bloating, muscular aches

2 caplets PO q4-6hr prn; not to exceed 8 caplets/24 hr

Dosage Forms & Strengths

acetaminophen/magnesium salicylate/pamabrom

caplet

  • 250mg/250mg/25mg
more...

Menstrual Symptoms

Indicated for relief of symptoms associated with menstrual periods including cramps, headaches, backaches, water-weight gain, bloating, muscular aches

<12 years: Safety and efficacy not established

≥12 years: 2 caplets PO q4-6hr prn; not to exceed 8 caplets/24 hr

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Interactions

Interaction Checker

and acetaminophen/magnesium salicylate/pamabrom

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            Adverse Effects

            Frequency Not Defined

            Angioedema

            Laryngeal edema

            Pruritic maculopapular rash

            Urticaria

            Anaphylactoid reaction

            Agranulocytosis

            Leukopenia

            Neutropenia

            Pancytopenia

            Thrombocytopenia

            Thrombocytopenic purpura

            Hepatotoxicity

            Tinnitus (high or chronic dose)

            Dyspepsia

            Heartburn

            Nausea

            Vomiting

            Stomach pain

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            Warnings

            Contraindications

            Hypersensitivity/allergy to salicylates or other ingredients

            Cautions

            Contains aspirin; children and adolescents should not use for symptoms of viral infections (eg, chickenpox, influenza) due to risk for Reye syndrome

            Hepatic impairment or consumption of 3 or more alcoholic beverages/day may increase risk for liver damage (associated with acetaminophen) or GI bleeding (associated with magnesium salicylate)

            Acetaminophen: Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash

            Do not take with other products that contain acetaminophen due to risk of additive toxicity/overdose

            Avoid with active peptic ulcer disease

            Avoid in severe renal impairment (ie, CrCl <10 mL/min)

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            Pregnancy & Lactation

            Pregnancy Category: D; avoid aspiring (NSAIDs) during pregnancy, particularly in third trimester because of risk for premature closure of the ductus arteriosus

            Lactation: excreted in breast milk

            Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Acetaminophen: Acts on hypothalamus to produce antipyresis

            Magnesium salicylate: Acts on hypothalamus to produce antipyresis; anti-inflammatory properties attributed to prostaglandin synthetase inhibition resulting in decreased formation of thromboxane A2

            Pamabrom: Weak diuretic action

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