magnesium salicylate/pamabrom (Discontinued)

Brand and Other Names:Pamprin Maximum Pain Relief Caplets
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Dosing & Uses

AdultPediatric

Dosing Forms & Strength

magnesium salicylate/pamabrom

tablet

  • 250mg/25mg

Analgesia/Menstrual Cramps

1-2 tablets PO q4-6hr PRN

Safetyand efficacy not established

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Adverse Effects

Frequency Not Defined (common)

Tinnitus (high or chronic dose)

Rash

Urticaria

Dyspepsia

Heartburn

Nausea

Vomiting

Stomach pain

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Warnings

Contraindications

Hypersensitivity

Repeated administration in patients with anemia, pulmonary, cardiac conditions, or renal disease

Cautions

Gastrointestinal bleeding; particular caution in patients with history of GI bleed, alcoholism, or bleeding disorders

Avoid with active peptic ulcer disease, severe hepatic impairment, and severe renal impairment (ie, CrCl<10 mL/min)

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Pregnancy & Lactation

Pregnancy category: D; avoid during pregnancy, particularly in third trimester because of risk for premature closure of the ductus arteriosus

Lactation: Excreted in breast milk; not recommended

Seek advice of health professional before using OTC drugs if pregnant or breastfeeding

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Mechanism of Action

Magnesium salicylate: Nonsteroidal anti-inflammatory agent (NSAID) with analgesic and antipyretic properties.

Pamabrom: Weak diuretic action

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Images

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