alitretinoin topical (Rx)

Brand and Other Names:Panretin
  • Print

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

gel

  • 0.1%
more...

AIDS-Related Kaposi's Sarcoma

Initially apply q12hr to lesions; may increase to q6-8hr depending on individual lesion tolerance; frequency may be reduced if toxicity occurs

T-Cell Lymphomas (Off-label)

Apply q12 hr to cutaneous lesions

Safety & efficacy not established

Next:

Adverse Effects

>10%

Rash (25-77%)

Pruritus (8-11%)

Paresthesia (3-22%)

Pain (<34%)

Pruritus (11%)

1-10%

Exfoliative dermatitis (3-9%)

Edema (3-8%)

Skin disorders (8%)

Paresthesia (3%)

Previous
Next:

Warnings

Contraindications

Hypersensitivity to retinoids

Concomitant systemic anti-Kaposi's sarcoma treatment

Pregnancy

Cautions

Minimize treated area exposure to sun or other sources of UV

Not for concurrent use with DEET products

Use precautions for handling and disoposal

Safety not established in children or the elderly

Handle with caution and dispose appropriately

Previous
Next:

Pregnancy & Lactation

Pregnancy Category: D

Lactation: excretion in milk unknown/not recommended

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

more...
Previous
Next:

Pharmacology

Mechanism of Action

Binds to retinoid receptors, which in turn promotes cellular differentiation and inhibits growth of Kaposi's sarcoma

Pharmacokinetics

Onset: 2-14 wk

Absorption: Negligible

Metabolism: In vitro data unlikely relevant since little absorption

Previous
Next:

Images

Previous
Next:

Formulary

FormularyPatient Discounts

Adding plans allows you to compare formulary status to other drugs in the same class.

To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

Adding plans allows you to:

  • View the formulary and any restrictions for each plan.
  • Manage and view all your plans together – even plans in different states.
  • Compare formulary status to other drugs in the same class.
  • Access your plan list on any device – mobile or desktop.

The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
Additional Offers
Email to Patient

From:

To:

The recipient will receive more details and instructions to access this offer.

By clicking send, you acknowledge that you have permission to email the recipient with this information.

Email Forms to Patient

From:

To:

The recipient will receive more details and instructions to access this offer.

By clicking send, you acknowledge that you have permission to email the recipient with this information.

Previous