Dosing & Uses
Dosage Forms & Strengths
AIDS-Related Kaposi's Sarcoma
Initially apply q12hr to lesions; may increase to q6-8hr depending on individual lesion tolerance; frequency may be reduced if toxicity occurs
T-Cell Lymphomas (Off-label)
Apply q12 hr to cutaneous lesions
Safety & efficacy not established
Exfoliative dermatitis (3-9%)
Skin disorders (8%)
Hypersensitivity to retinoids
Concomitant systemic anti-Kaposi's sarcoma treatment
Minimize treated area exposure to sun or other sources of UV
Not for concurrent use with DEET products
Use precautions for handling and disoposal
Safety not established in children or the elderly
Handle with caution and dispose appropriately
Pregnancy & Lactation
Pregnancy Category: D
Lactation: excretion in milk unknown/not recommended
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Binds to retinoid receptors, which in turn promotes cellular differentiation and inhibits growth of Kaposi's sarcoma
Onset: 2-14 wk
Metabolism: In vitro data unlikely relevant since little absorption
Adding plans allows you to compare formulary status to other drugs in the same class.
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Adding plans allows you to:
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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.
|1||This drug is available at the lowest co-pay. Most commonly, these are generic drugs.|
|2||This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.|
|3||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.|
|4||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|5||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|6||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|NC||NOT COVERED – Drugs that are not covered by the plan.|
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.