Brand and Other Names:Pediazole
- Classes: Sulfonamides
Dosing & Uses
Not prescribed for adults
Serious - Use Alternative
Significant - Monitor Closely
Frequency Not Defined
Abdominal pain and discomfort
Lack or loss of appetite
Blood or stone formation in urine
Bluish discoloration of skin
Difficulty/inability to urinate
Redness & swelling of tongue
Sensitivity to light
Severe allergic reactions
Severe skin welts or swelling
Shortness of breath
Swelling around the eye
Temporary hearing loss
Hypersensitivity to macrolides, sulfonamides, sulfonylureas, thiazides
Age <2 months
Severe hepatic or renal impairment (CrCl <15 mL/min), documented megaloblastic or folate deficiency anemia, obstructive uropathy
Pregnancy & Lactation
Pregnancy Category: C
Lactation: enters breast milk
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Half-Life: 1-1.5 hr (erythromycin); 4.6-7.8 hr (sulfisoxazole)
Protein bound: 75-90% (erythromycin); 855 (sulfisoxazole)
Protein Bound: 75-90%
Peak Plasma Time of erythromycin: base: 4 hr; ethylsuccinate: 0.5-2.5 hr; delayed with food due to differences in absorption
Metabolized: in liver by demethylation (erythromycin); conjugated in liver (sulfisoxazole)
- Unchanged drug excreted and concentrated in bile
- Urine: <5%
- Urine: 50% in urine as unchanged drug
Mechanism of Action
Erythromycin: Erythromycin: Macrolide antibiotic; iInhibits bacterial growth, possibly by blocking dissociation of peptidyl tRNA from ribosomes, causing RNA-dependent protein synthesis to arrest
Sulfisoxazole: Sulfonamide derivative; exerts bacteriostatic action by antagonizing para-aminobenzoic acid (PABA), an essential component in folic acid synthesis
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|1||This drug is available at the lowest co-pay. Most commonly, these are generic drugs.|
|2||This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.|
|3||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.|
|4||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|5||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|6||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|NC||NOT COVERED – Drugs that are not covered by the plan.|
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