Close
New

Medscape is available in 5 Language Editions – Choose your Edition here.

 

penicillin VK (Rx)Brand and Other Names:Pen Vee K, Penicillin V, more...Veetids

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

oral solution

  • 125mg/5mL
  • 250mg/5mL

tablet

  • 250mg
  • 500mg
more...

Streptococcal Pharyngitis

500 mg PO q12hr or 250 mg PO q6hr for 10 days

Actinomycosis

Mild: 2-4 g/day PO divided q6hr for 8 weeks

Surgical: 2-4 g/day PO divided q6hr for 6-12 months

Erysipelas

500 mg PO q6hr

Periodontal Infections

250-500 mg PO q6hr for 5-7 days

Recurrent Rheumatic Fever

Prophylaxis

250 mg PO q12hr

Prosthetic Joint Infection (Off-label)

500 mg PO q6-12hr

Dosing Considerations

Monitor renal and hematologic systems

Administration

Take on empty stomach

Dosage Forms & Strengths

oral solution

  • 125mg/5mL
  • 250mg/5mL

tablet

  • 250mg
  • 500mg
more...

Pneumococcal Systemic Infections

<12 years

  • 50-75 mg/kg/day PO q6-8hr 
  • Not to exceed 3 g/day

>12 years

  • 250-500 mg PO q6-8hr until the patient is afebrile for at least 2 days

Pneumococcal Infection Prophylaxis

<5 years: 125 mg PO q12hr

>5 years: 250 mg PO q12hr

Streptococcal Pharyngitis

Children: 250 mg PO q8-12hr for 10 days

Adolescents: 250 mg PO q6hr or 500 mg PO q12hr for 10 days

Rheumatic Fever

Primary prevention

<5 years: 125 mg q12hr PO for 10 days

>5 years: 250 mg q12hr PO for 10 days

Recurrent Rheumatic Fever

Prophylaxis

Children: 125-250 mg PO q12hr on a continuing basis

Administration

Take on empty stomach

Next

Interactions

Interaction Checker

penicillin VK and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            Sort by :  
             activity indicator 
            Previous
            Next

            Adverse Effects

            Frequency Not Defined

            Diarrhea

            Nausea

            Oral candidiasis

            Vomiting

            Seizure

            Anemia

            Interstitial nephritis

            Hypersensitivity

            Anaphylaxis

            Positive Coombs reaction

            Previous
            Next

            Warnings

            Contraindications

            Allergy to penicillins, cephalosporins, or imipenem

            Cautions

            Caution in severe renal impairment

            Prolonged use may result in superinfection

            Use with caution in patients with asthma history; IGE mediated anaphylactic reactions (eg, urticaria, anaphylaxis) reported

            Use with caution in neonates; some dosage forms may contain sodium benzoate/benzoic acid, which may cause fatal toxicity (gasping syndrome) when used in large amounts

            Adverse effects, including hemolytic anemia, serum sickness, or neutropenia, may occur with prolonged use; serum concentrations may increase with extended duration of therapy, especially in patients with renal insufficiency

            Use caution in patients with history of seizure disorders; high serum levels, especially in the presence of renal impairment, may increase risk of seizures

            Previous
            Next

            Pregnancy & Lactation

            Pregnancy category: B

            Lactation: Excreted in breast milk; compatible with breastfeeding

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
            Previous
            Next

            Pharmacology

            Mechanism of Action

            Inhibits the biosynthesis of cell wall mucopeptide; bactericidal against sensitive organisms when adequate concentrations are reached, and most effective during the stage of active multiplication; inadequate concentrations may produce only bacteriostatic effects.

            Absorption

            Bioavailability: 60-73%

            Peak plasma time: 0.5-1 hr

            Distribution

            Protein bound: 80%

            Crosses placenta; poor blood-brain barrier diffusion

            Metabolism

            Hepatic

            Elimination

            Half-life: 0.5-0.6 hr

            Excretion: Urine

            Previous
            Next

            Images

            Previous
            Next

            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
            Add or Remove Plans
            Plans for
            Select State:
            Non-Medicare PlansMedicare Plans

            Select a box to add or remove a plan.

            Select a class to view formulary status for similar drugs

            Additional Offers
            Email to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Email Forms to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Previous
             
             
             
            All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.