magnesium salicylate (OTC)

Brand and Other Names:Doan's Extra Strength, Percogesic Maximum Strength Backache Relief
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 325 mg
  • 580 mg as tetrahydrate (equal to 467.2 mg anhydrous magnesium salicylate)
  • 600 mg
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Mild-to-Moderate Pain

2 tabs PO q6hr PRN; not to exceed 8 tabs/24 hr

Dosage Forms & Strengths

tablet

  • 325 mg
  • 580 mg as tetrahydrate (equal to 467.2 mg anhydrous magnesium salicylate)
  • 600 mg
more...

Mild-to-Moderate Pain

<12 years: Safety and efficacy not established

>12 years: 2 tabs PO q6hr PRN; not to exceed 8 tabs/24 hr

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Interactions

Interaction Checker

and magnesium salicylate

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            Warnings

            Contraindications

            Hypersensitivity

            Advanced chronic renal impairment

            Coadministration with uricosuric agents

            Elderly patients (65 years or older) with carditis, hepatic impairment

            Children and adolescents with viral illness (eg, varicella, influenza); increased risk for Reye’s syndrome

            Cautions

            Chronic ingestion of salicylates in patients older than 65 years may cause noncardiogenic pulmonary edema

            May cause GI ulceration or bleeding

            Consuming 3 or more alcoholic drinks daily may increase risk for GI bleeding

            Caution in patients with asthma; may have increased risk for hypersensitivity or exacerbation of asthma

            Do not take if on other chronic NSAIDs

            Caution if coadministered with anticoagulant drugs

            May cause tinnitus

            Use caution in patients with dehydration, erosive gastritis or peptic ulcer

            Heart Failure (HF) risk

            • NSAIDS have the potential to trigger HF by prostaglandin inhibition that leads to sodium and water retention, increased systemic vascular resistance, and blunted response to diuretics
            • High dose salicylates should be avoided or withdrawn whenever possible
            • AHA/ACC Heart Failure Guidelines; Circulation. 2016; 134
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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Salicylates are excreted in breast milk; caution advised

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            NSAID with antipyretic and analgesic properties via central and peripheral effects

            Absorption

            Absorbed rapidly

            Peak Plasma Time: 1.5 hr (salicylic acid metabolite)

            Peak Plasma Concentration: 3.6 mg/dL (salicylic acid metabolite)

            Distribution

            Protein Bound: 50-90%

            Metabolism

            Released in plasma as salicylic acid, which is then enzymatically metabolized to salicyluric acid and salicylphenolic glucuronide

            Elimination

            Half-life: 2 hr (salicylic acid metabolite); half-life prolonged with repeated dosing

            Excretion: Urine

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