Dosing & Uses
Dosage Forms & Strengths
- <300mg/capsule (total amino acids)
- Formulation consists of nonessential and essential amino acids L-arginine HCL, L-histidine HCl, L-glutamine, L-serine, L-lysine, L-ornithine, acetyl L-carnitine, L-tyrosine, the nonstandard amino acid gamma aminobutyric acid, choline bitartrate, glucose, inositol, Griffonia extract Griffonia simplicifolia (95% 5-hydroxytryptophan [serotonin precursor]) , and creatinine
Medical food product indicated for clinical dietary management of the metabolic processes of pain, inflammation and loss of sensation due to peripheral neuropathy
2 capsules PO BID
Take on empty stomach to maximize absorption of amino acids
Store in tightly closed original container in cool, dry location 8-32 degrees C (45-90 degrees F), with relative humidity <50%
Safety and efficacy not established
Frequency Not Defined
Nausea, abdominal cramps, and diarrhea may occur with high doses (ie, 15 g/day); recommended daily dose of Percura is ~1.2 g/day
Temporary rash (~0.02%) after increased histamine exposure; subsides ≤24 hr
Documented hypersensitivity to any of the nutritional components
Pregnancy & Lactation
Pregnancy Category: C
Lactation: Unknown whether distributed in breast milk
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Provides nutritional requirements that support neurotransmitter synthesis and physiological activities involved in neuropathic pain; helps restore nutrient balance of arginine, choline, glutamine, histidine, tryptophan, and serine which support the balance of the neurotransmitters GABA, histamine, nitric oxide, serotonin, and acetylcholine
Under usual physiological conditions, glutamine, arginine, serine, and choline are considered nonessential because endogenous synthesis is sufficient to satisfy metabolic demand; with neuropathic pain, the usual rate of synthesis is no longer sufficient and these nutrients become conditionally essential, requiring that supplemental amounts be consumed
Amino acids absorbed in stomach and small intestines
Circulating tryptophan, arginine and choline blood levels determine the production of serotonin, nitric oxide, and acetylcholine
Amino acids metabolized by most cells in the body
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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.
|1||This drug is available at the lowest co-pay. Most commonly, these are generic drugs.|
|2||This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.|
|3||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.|
|4||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|5||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|6||This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.|
|NC||NOT COVERED – Drugs that are not covered by the plan.|
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.