amino acids mixture (Rx)

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Brand and Other Names:Percura

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

capsule

  • <300mg/capsule (total amino acids)
  • Formulation consists of nonessential and essential amino acids L-arginine HCL, L-histidine HCl, L-glutamine, L-serine, L-lysine, L-ornithine, acetyl L-carnitine, L-tyrosine, the nonstandard amino acid gamma aminobutyric acid, choline bitartrate, glucose, inositol, Griffonia extract Griffonia simplicifolia (95% 5-hydroxytryptophan [serotonin precursor]) , and creatinine
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Neuropathic Pain

Medical food product indicated for clinical dietary management of the metabolic processes of pain, inflammation and loss of sensation due to peripheral neuropathy

2 capsules PO BID

Administration

Take on empty stomach to maximize absorption of amino acids

Store in tightly closed original container in cool, dry location 8-32 degrees C (45-90 degrees F), with relative humidity <50%

Safety and efficacy not established

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Adverse Effects

Frequency Not Defined

Nausea, abdominal cramps, and diarrhea may occur with high doses (ie, 15 g/day); recommended daily dose of Percura is ~1.2 g/day

Postmarketing Reports

Temporary rash (~0.02%) after increased histamine exposure; subsides ≤24 hr

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Warnings

Contraindications

Documented hypersensitivity to any of the nutritional components

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: Unknown whether distributed in breast milk

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Mechanism of Action

Provides nutritional requirements that support neurotransmitter synthesis and physiological activities involved in neuropathic pain; helps restore nutrient balance of arginine, choline, glutamine, histidine, tryptophan, and serine which support the balance of the neurotransmitters GABA, histamine, nitric oxide, serotonin, and acetylcholine

Under usual physiological conditions, glutamine, arginine, serine, and choline are considered nonessential because endogenous synthesis is sufficient to satisfy metabolic demand; with neuropathic pain, the usual rate of synthesis is no longer sufficient and these nutrients become conditionally essential, requiring that supplemental amounts be consumed

Absorption

Amino acids absorbed in stomach and small intestines

Metabolism

Circulating tryptophan, arginine and choline blood levels determine the production of serotonin, nitric oxide, and acetylcholine

Amino acids metabolized by most cells in the body

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Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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