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senna/docusate (OTC)Brand and Other Names:PeriColace, Senna Plus, more...Senna-S, Senokot-S

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

senna/docusate

tablet

  • 8.6mg/50mg
more...

Constipation

2-4 tablets PO qDay; may increase to 4 tab q12hr

Dosage Forms & Strengths

senna/docusate

tablet

  • 8.6mg/50mg
more...

Constipation

<2 years: Safety & efficacy not established

2-6 years: One-half tablet PO qDay; may increase to maximum 1 tab q12hr

6-12 years: One tablet PO qDay may increase as necessary; not to exceed 2 tabs q12hr

>12 years: As adults; 2-4 tablets PO qDay or q12hr

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Interactions

Interaction Checker

senna/docusate and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Abdominal cramping

            Diarrhea

            Nausea/vomiting

            Yellow-brown urine discoloration

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            Warnings

            Contraindications

            Hypersensitivity

            GI obstruction or perforation

            Ulcerative colitis

            Symptoms of appendicitis or acute surgical abdomen

            Fecal impaction

            Concurrent use of mineral oil

            GI bleeding

            Rectal bleeding

            Cautions

            Finger clubbing (long-term use)

            Not for use as over the counter in patients experiencing abdominal pain, vomiting, nausea, sudden change in bowel movement that last > 2 weeks

            Not recommended for use >1 week or children < 2 years

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            Pregnancy & Lactation

            Pregnancy category: N/A

            Lactation: unknown if excreted in breast milk; not recommended

            Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Senna: intestinal irritant/stimulant

            Docusate: surfactant laxative/stool softener

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