Brand and Other Names:Peridex, PerioGard, more...PerioChip
- Classes: Antibiotics, Oral Rinse
Dosing & Uses
Dosage Forms & Strengths
Peridex, PerioGard: PO rinse 15 mL q12hr
Adjunct to Scaling & Root Planing
PerioChip: 1-8 chips in periodontal pocket, depth >5 mm; repeat q3Months
Oral Mucositis (Orphan)
Amelioration of oral mucositis associated with cytoreductive therapy used in conditioning patients for bone marrow transplantation therapy
Orphan indication sponsor
- Procter & Gamble Company; Sharon Wood Technical Center, 11370 Reed Hartman Highway; Cincinnati, OH 45241
Safety and efficacy not established
Serious - Use Alternative
Significant - Monitor Closely
Increased tartar on teeth
Skin and oral irritation
Staining of tooth
Taste sense altered
Increase in calculus formation
Glossal edema, and paresthesia
Grossly obvious gingivitis
Anaphylaxis and serious allergic reactions reported (see Contraindications)
Extended-release pellets: Anaphylaxis and serious allergic reactions reported during postmarketing surveillance
Increase of tartar on teeth
Changes in taste
Staining of oral surfaces (mucosa, teeth, dorsum of tongue) may be visible as soon as 1wk after therapy begins and is more pronounced when there is a heavy accumulation of unremoved plaque and when teeth fillings have rough surfaces; stain does not have a clinically adverse effect but because removal may not be possible, patient with frontal restoration should be advised of the potential permanency of the stain
Pregnancy & Lactation
Pregnancy Category: C
Lactation: excretion in milk unknown; use with caution
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Polybiguanide antiseptic and antimicrobial drug with bactericidal activity; binds to the negatively charged bacterial cell walls and extramicrobial complexes
Absorption: ~30% retained in the oral cavity following rinsing and slowly released into oral fluids; poorly absorbed
Time to peak, plasma: Oral rinse: Detectable levels not present after 12 hr
Excretion: Feces (~90%); urine (<1%)
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