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chlorhexidine oral (Rx)Brand and Other Names:Peridex, PerioGard, more...PerioChip

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

oral solution

  • 0.12%

chip

  • 2.5mg
more...

Gingivitis

Peridex, PerioGard: PO rinse 15 mL q12hr

Adjunct to Scaling & Root Planing

PerioChip: 1-8 chips in periodontal pocket, depth >5 mm; repeat q3Months

Oral Mucositis (Orphan)

Amelioration of oral mucositis associated with cytoreductive therapy used in conditioning patients for bone marrow transplantation therapy

Orphan indication sponsor

  • Procter & Gamble Company; Sharon Wood Technical Center, 11370 Reed Hartman Highway; Cincinnati, OH 45241

Safety and efficacy not established

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Interactions

Interaction Checker

chlorhexidine oral and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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             activity indicator 
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            Adverse Effects

            >10%

            Increased tartar on teeth

            1-10%

            Skin and oral irritation

            Staining of tooth

            Bronchitis

            Taste sense altered

            Toothache

            Increase in calculus formation

            <1%

            Stomatitis

            Gingivitis

            Glossitis

            Aphthous ulcer

            Dry mouth

            Hypesthesia

            Glossal edema, and paresthesia

            Grossly obvious gingivitis

            Desquamation

            Coated tongue

            Keratinization

            Geographic tongue

            Mucocele

            Anaphylaxis

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            Warnings

            Contraindications

            Hypersensitivity

            Cautions

            Anaphylaxis and serious allergic reactions reported (see Contraindications)

            Extended-release pellets: Anaphylaxis and serious allergic reactions reported during postmarketing surveillance

            Increase of tartar on teeth

            Changes in taste

            Staining of oral surfaces (mucosa, teeth, dorsum of tongue) may be visible as soon as 1wk after therapy begins and is more pronounced when there is a heavy accumulation of unremoved plaque and when teeth fillings have rough surfaces; stain does not have a clinically adverse effect but because removal may not be possible, patient with frontal restoration should be advised of the potential permanency of the stain

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: excretion in milk unknown; use with caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Mechanism of Action

            Polybiguanide antiseptic and antimicrobial drug with bactericidal activity; binds to the negatively charged bacterial cell walls and extramicrobial complexes

            Pharmacokinetics

            Absorption: ~30% retained in the oral cavity following rinsing and slowly released into oral fluids; poorly absorbed

            Time to peak, plasma: Oral rinse: Detectable levels not present after 12 hr

            Excretion: Feces (~90%); urine (<1%)

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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