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dipyridamole (Rx)Brand and Other Names:Persantine

 
 
 

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

injectable solution

  • 5mg/mL

tablet

  • 25mg
  • 50mg
  • 75mg
more...

Thromboembolism Prophylaxis Post-Cardiac Valve Replacement

75-100 mg PO q6hr as adjunct to warfarin

Adjunct to Thallium Myocardial Perfusion Imaging (Off-label)

Adjusted according to body weight; recommended 0.142 mg/kg/min IV infusion over 4 minutes; not to exceed 60 mg

Other Indications & Uses

Prevention of MI recurrence (in combo with aspirin): No benefit over aspirin alone

See also combo with aspirin

Dosage Forms & Strengths

injectable solution

  • 5mg/mL

tablet

  • 25mg
  • 50mg
  • 75mg
more...

Off-label Use

3-6 mg/kg/day PO divided q6-8hr

Avoid short-acting products; causes orthostatic hypotensio and more effective alternatives available; IV form acceptable for cardiac stress testing (Beers criteria)

Thromboembolism prophylaxis post-cardiac valve replacement

75-100 mg PO q6hr as adjunct to warfarin

Adjunct to thallium myocardial perfusion imaging (Off-label)

Adjusted according to body weight; recommended 0.142 mg/kg/min IV infusion over 4 minutes; no more than 60 mg

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Interactions

Interaction Checker

dipyridamole and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Chest pain (20%)

            Angina exacerbation, IV (19.7%)

            Abnormal ECG (15.9%)

            Headache, IV (12.2%)

            Dizziness (12%)

            1-10%

            ST-T changes (7.5%)

            Abdominal discomfort, oral (6.1%)

            Extrasystole (5%)

            Nausea, IV (4.6%)

            Hypotension, IV (4.6%)

            Flushing (3.4%)

            Generalized pain (2.6%)

            Headache, oral (2.3%)

            Frequency Not Defined

            Myocardial infarction (rare)

            Ventricular arrhythmia (rare)

            Bronchospasm (rare)

            Dyspnea

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            Warnings

            Contraindications

            Hypersensitivity

            Thrombocytopenia

            Cautions

            FDA approval for chronic angina withdrawn (not useful according to most experts)

            Risk of AMI in CAD patients with IV

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            Pregnancy & Lactation

            Pregnancy Category: B

            Lactation: enters breast milk; use with caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
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            Pharmacology

            Mechanism of Action

            Non-nitrate coronary vasodilator

            • Inhibition of RBC uptake of adenosine thereby inhibiting platelet reactivity
            • Phosphodiesterase inhibition increasing cAMP in platelet, OR
            • Inhibition of Thromboxane A2 formation (vasoconstrictor and a stimulator of platelet activation)

            Pharmacokinetics

            Half-life elimination: 10-12hr

            Peak time: 2-2.5 hr

            Onset: 3 months

            Duration: 6 hr

            Protein Bound: 99%

            Vd: 2-3 L/kg

            Clearance: 2.3-3.5 mL/min/kg

            Excretion: Feces

            Dialyzable: No

            Metabolism: Liver

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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